rs224136

Orientation

plus

Stabilized

plus

Make rs224136(C;C)

Make rs224136(C;T)

Make rs224136(T;T)

Reference

GRCh38 38.1/142

Chromosome

10

Position

62710915

is a	snp
is	mentioned by
dbSNP	rs224136
dbSNP (classic)	rs224136
ClinGen	rs224136
ebi	rs224136
HLI	rs224136
Exac	rs224136
Gnomad	rs224136
Varsome	rs224136
LitVar	rs224136
Map	rs224136
PheGenI	rs224136
Biobank	rs224136
1000 genomes	rs224136
hgdp	rs224136
ensembl	rs224136
geneview	rs224136
scholar	rs224136
google	rs224136
pharmgkb	rs224136
gwascentral	rs224136
openSNP	rs224136
23andMe	rs224136
SNPshot	rs224136
SNPdbe	rs224136
MSV3d	rs224136
GWAS Ctlg	rs224136

GMAF

0.3577

Max Magnitude

0

?	(C;C) (C;T) (T;T)	28

Rs224136
PubMed	[PMID 17435756]
Affy Probeset	SNP_A-1883807
Affy Orientation	reverse
On GW 5.0	1
Alleles A/B	A/G
Ancestral	T
Population	EU
Allele	C
Case Freq.	0.87
Control Freq.	0.81
Odds Ratio Het
Odds Ratio Hom
Odds Ratio All	1.67
Disease	Crohn's disease (CD)

Carriers of the C allele of rs224136 reportedly have 1.67 times higher susceptibility to Crohn's disease. [PMID 17435756]

Rs224136 is not a major genetic risk factor for susceptibility to Crohn's disease in the German population. [PMID 19262523]

GWAS
SNP	rs224136
PubMedID	[PMID 17435756]
Condition	Crohn's disease
Gene	Intergenic
Risk Allele
pValue	1.00E-010
OR	1.67
95% CI

OMIM	612255
Desc	INFLAMMATORY BOWEL DISEASE 15; IBD15
Variant
Related	also

OMIM	266600
Desc	INFLAMMATORY BOWEL DISEASE 1; IBD1
Variant
Related	also

[PMID 17068223] A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.

[PMID 20195480] The cannabinoid 1 receptor (CNR1) 1359 G/A polymorphism modulates susceptibility to ulcerative colitis and the phenotype in Crohn's disease.

[PMID 20222171] T300A polymorphism of ATG16L1 and susceptibility to inflammatory bowel diseases: a meta-analysis.