rs2718058
From SNPedia
| Orientation | plus |
| Stabilized | plus |
| Make rs2718058(A;A) |
| Make rs2718058(A;G) |
| Make rs2718058(G;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 7 |
| Position | 37801932 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs2718058 |
| dbSNP (classic) | rs2718058 |
| ClinGen | rs2718058 |
| ebi | rs2718058 |
| HLI | rs2718058 |
| Exac | rs2718058 |
| Gnomad | rs2718058 |
| Varsome | rs2718058 |
| LitVar | rs2718058 |
| Map | rs2718058 |
| PheGenI | rs2718058 |
| Biobank | rs2718058 |
| 1000 genomes | rs2718058 |
| hgdp | rs2718058 |
| ensembl | rs2718058 |
| geneview | rs2718058 |
| scholar | rs2718058 |
| rs2718058 | |
| pharmgkb | rs2718058 |
| gwascentral | rs2718058 |
| openSNP | rs2718058 |
| 23andMe | rs2718058 |
| SNPshot | rs2718058 |
| SNPdbe | rs2718058 |
| MSV3d | rs2718058 |
| GWAS Ctlg | rs2718058 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
| GWAS snp | |
|---|---|
| PMID | [PMID 24162737 ]
|
| Trait | Alzheimer's disease (late onset) |
| Title | Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. |
| Risk Allele | A |
| P-val | 5E-9 |
| Odds Ratio | 1.08 [1.05-1.11] |
A study in a North Han Chinese population (
[PMID 27144521] ) failed to replicate an association between rs2718058 and late-onset Alzheimer's disease (LOAD) risk that had originally been identified in a Caucasian population. The same group's meta-analysis confirmed a significant if modest association between SNP rs2718058 and LOAD risk (OR = 1.08, 95%CI = 1.05–1.11) in the whole meta-analysis population, but still found only a nonsignificant trend in the Chinese subgroup (OR = 1.05, 95%CI = 0.93–1.17).
