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From SNPedia

Geno Mag Summary
(C;C) 2.5 higher cancer risk ? (ambiguous flip)
(C;G) higher/earlier cancer likelihood??
(G;G) 0 normal
ReferenceGRCh38 38.1/141
GeneMIR146A, MIR3142HG
is asnp
is mentioned by
dbSNP (classic)rs2910164
1000 genomesrs2910164
GWAS Ctlgrs2910164
Max Magnitude2.5
? (C;C) (C;G) (G;G) 28

[PMID 18474871OA-icon.png] (C;C) predisposes to papillary thyroid carcinoma.

[PMID 18660546] Among 42 patients with familial breast cancer and 82 patients with ovarian cancer, those with at least one rs2910164(C) SNP tended to have been diagnosed at an earlier age than those with only (G) alleles. For the breast cancer patients, the difference in median age was between 45 vs 56 (p = 0.029) and for ovarian cancer patients, 45 vs 50, (p = 0.014).

[PMID 18711148] (G;G) males were two-fold more susceptible to hepatocellular carcinoma (OR = 2.016, 95% CI = 1.056-3.848, P = 0.034)

perhaps an ambiguous flip?

snp near microRNA
ACC MI0000477
ID hsa-mir-146a
offset -10

[PMID 19293314] A Functional Genetic Variant in microRNA-196a2 Is Associated with Increased Susceptibility of Lung Cancer in Chinese.

[PMID 19514064] Functional variant in microRNA-196a2 contributes to the susceptibility of congenital heart disease in a Chinese population


[PMID 19847796] Evaluation of SNPs in miR-146a, miR196a2 and miR-499 as low-penetrance alleles in German and Italian familial breast cancer cases

[PMID 19902466] A functional polymorphism in Pre-miR-146a gene is associated with prostate cancer risk and mature miR-146a expression in vivo

[PMID 20011700] Analyses of polymorphisms in the inflammasome-associated NLRP3 and miRNA-146A genes in the susceptibility to and tubal pathology of Chlamydia trachomatis infection

[PMID 20488170] Common genetic polymorphisms in pre-microRNAs were associated with increased risk of dilated cardiomyopathy

[PMID 20500689] The Role of microRNA-146a (miR-146a) and its Target IL-1R-Associated Kinase (IRAK1) in Psoriatic Arthritis Susceptibility

[PMID 20549817OA-icon.png] Genetic variants in selected pre-microRNA genes and the risk of squamous cell carcinoma of the head and neck

[PMID 20640596] The association between two polymorphisms in pre-miRNAs and breast cancer risk: a meta-analysis

[PMID 20680470] A functional varient in microRNA-146a is associated with risk of esophageal squamous cell carcinoma in Chinese Han

[PMID 20842445] Genetic variation in microRNA genes and prostate cancer risk in North Indian population

[PMID 20848167] Association Study of Common Genetic Variants in Pre-microRNAs in Patients with Ulcerative Colitis

[PMID 20870441] A polymorphism in the 3'-UTR of interleukin-1 receptor-associated kinase (IRAK1), a target gene of miR-146a, is associated with rheumatoid arthritis susceptibility

[PMID 21073609] Association Between Common Genetic Variants in Pre-microRNAs and Gastric Cancer Risk in Japanese Population

[PMID 21524676] Genetic study of two single nucleotide polymorphisms within corresponding microRNAs and susceptibility to tuberculosis in a Chinese Tibetan and Han population

[PMID 21591024] The rs2910164:G>C SNP in the MIR146A gene is not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers

[PMID 21637771OA-icon.png] Effects of Common Polymorphisms rs11614913 in miR-196a2 and rs2910164 in miR-146a on Cancer Susceptibility: A Meta-Analysis

[PMID 21744077OA-icon.png] A functional polymorphism in the pre-miR-146a gene is associated with risk and prognosis in adult glioma

[PMID 21807077] No association of pre-microRNA-146a rs2910164 polymorphism and risk of hepatocellular carcinoma development in Turkish population: A case-control study

[PMID 21861697OA-icon.png] Association Between Two Genetic Variants in miRNA and Primary Liver Cancer Risk in the Chinese Population

[PMID 22218224OA-icon.png] Genetic association of miRNA-146a with systemic lupus erythematosus in Europeans through decreased expression of the gene

[PMID 22282540OA-icon.png] Thyroid cancer susceptibility polymorphisms: confirmation of loci on chromosomes 9q22 and 14q13, validation of a recessive 8q24 locus and failure to replicate a locus on 5q24

[PMID 22182931] Association between the rs2910164 polymorphism in pre-mir-146a and oral carcinoma progression.

[PMID 22291993OA-icon.png] A Genetic Variant in miR-196a2 Increased Digestive System Cancer Risks: A Meta-Analysis of 15 Case-Control Studies

[PMID 22363415OA-icon.png] Differential Expression Profile and Genetic Variants of MicroRNAs Sequences in Breast Cancer Patients

[PMID 22363684OA-icon.png] Increased Risk of Breast Cancer Associated with CC Genotype of Has-miR-146a Rs2910164 Polymorphism in Europeans

[PMID 22761848OA-icon.png] Lack of Association of miR-146a rs2910164 Polymorphism with Gastrointestinal Cancers: Evidence from 10206 Subjects

[PMID 22823586] MiR-146a polymorphism is associated with asthma but not with systemic lupus erythematosus and juvenile rheumatoid arthritis in Mexican patients

[PMID 18521189OA-icon.png] Genetic variants of miRNA sequences and non-small cell lung cancer survival.

[PMID 18634034] Common genetic variants in pre-microRNAs were associated with increased risk of breast cancer in Chinese women.

[PMID 19047128OA-icon.png] Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma.

[PMID 19138993OA-icon.png] Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk.

[PMID 19164563OA-icon.png] Polymorphic mature microRNAs from passenger strand of pre-miR-146a contribute to thyroid cancer.

[PMID 19232555OA-icon.png] Signatures of purifying and local positive selection in human miRNAs.

[PMID 19290790OA-icon.png] MicroRNA polymorphisms: the future of pharmacogenomics, molecular epidemiology and individualized medicine.

[PMID 19458495OA-icon.png] Comprehensive analysis of the impact of SNPs and CNVs on human microRNAs and their regulatory genes.

[PMID 19617315OA-icon.png] SNPs in human miRNA genes affect biogenesis and function.

[PMID 19881472] Common genetic variants in pre-microRNAs are associated with risk of coal workers' pneumoconiosis.

[PMID 20428464OA-icon.png] MicroRNA polymorphisms: a giant leap towards personalized medicine.

[PMID 20520619] Common genetic variants in pre-microRNAs and risk of gallbladder cancer in North Indian population.

[PMID 20721625] Combined effect of miR-146a rs2910164 G/C polymorphism and Toll-like receptor 4 +3725 G/C polymorphism on the risk of severe gastric atrophy in Japanese.

[PMID 20810544] Association between hsa-mir-146a genotype and tumor age-of-onset in BRCA1/BRCA2-negative familial breast and ovarian cancer patients.

[PMID 20845080] Association of pre-microRNAs genetic variants with susceptibility in systemic lupus erythematosus.

[PMID 21181275] Association study of single nucleotide polymorphisms in pre-miRNA and rheumatoid arthritis in a Han Chinese population.

[PMID 21319225] Common genetic polymorphisms in pre-microRNAs and risk of cervical squamous cell carcinoma.

[PMID 21345130] Investigative role of pre-microRNAs in bladder cancer patients: a case-control study in North India.

[PMID 21529907] Polymorphism of the pre-miR-146a is associated with risk of cervical cancer in a Chinese population.

[PMID 21663520] Association between single-nucleotide polymorphisms in pre-miRNAs and the risk of asthma in a Chinese population.

[PMID 21713406] Association between two single nucleotide polymorphisms at corresponding microRNA and schizophrenia in a Chinese population.

[PMID 21875645] Expression and genetic analysis of miRNAs involved in CD4+ cell activation in patients with multiple sclerosis.

[PMID 21902575] Genetic variants in miR-146a, miR-149, miR-196a2, miR-499 and their influence on relative expression in lung cancers.

[PMID 21947843] Has-miR-146a polymorphism (rs2910164) and cancer risk: a meta-analysis of 19 case-control studies.

[PMID 22019503] Association of polymorphisms in pre-miRNA with inflammatory biomarkers in rheumatoid arthritis in the Chinese Han population.

[PMID 23007982] Meta-analysis confirms that a common G/C variant in the pre-miR-146a gene contributes to cancer susceptibility and that ethnicity, gender and smoking status are risk factors

[PMID 22719192OA-icon.png] Evaluation of SNPs in miR-196-a2, miR-27a and miR-146a as risk factors of colorectal cancer

[PMID 23138379] Association of pre-miRNA-146a rs2910164 and pre‑miRNA-499 rs3746444 polymorphisms and susceptibility to rheumatoid arthritis

[PMID 22818121] The prognostic impact of microRNA sequence polymorphisms on the recurrence of patients with completely resected non-small cell lung cancer

[PMID 23262343] Relationship between genetic variant in pre-microRNA-146a and genetic predisposition to Temporal Lobe Epilepsy: A case-control study

[PMID 23267167] Association of pre-miR-146a rs2910164 Polymorphism with the Risk of Head and Neck Cancer

[PMID 23268366] MicroRNA-146a and Ets-1 gene polymorphisms in ocular Behcet's disease and Vogt-Koyanagi-Harada syndrome

[PMID 23437296OA-icon.png] The Association between Two Common Polymorphisms in MicroRNAs and Hepatocellular Carcinoma Risk in Asian Population

[PMID 23451063OA-icon.png] Association between the rs2910164 Polymorphism in Pre-Mir-146a Sequence and Thyroid Carcinogenesis

[PMID 23470291] Association between Genetic Variants in Pre-MicroRNAs and Survival of Early-Stage NSCLC

[PMID 23534761] The miR-146a rs2910164 G > C Polymorphism and Susceptibility to Digestive Cancer in Chinese

[PMID 23545308] Association between miR-146a rs2910164 Polymorphism and Autoimmune diseases susceptibility: a meta-analysis

[PMID 23219900OA-icon.png] Pre-microRNA variants predict HPV16-positive tumors and survival in patients with squamous cell carcinoma of the oropharynx

[PMID 23613822OA-icon.png] Genetic Polymorphisms of miR-146a and miR-27a, H. pylori Infection, and Risk of Gastric Lesions in a Chinese Population

[PMID 23613771OA-icon.png] Polymorphisms of microRNA Sequences or Binding Sites and Lung Cancer: A Meta-Analysis and Systematic Review

[PMID 23728616] Association between genetic variants in pre-miRNA and colorectal cancer risk in a Chinese population

[PMID 23888320] A functional polymorphism in the miR-146a gene is associated with the risk of childhood acute lymphoblastic leukemia: a preliminary report

[PMID 24102488] Meta-analysis of pre-miRNA polymorphisms association with susceptibility to autoimmune diseases

[PMID 24136745] Association between microRNA genetic variants and susceptibility to colorectal cancer in Chinese population

[PMID 23791656] Three common functional polymorphisms in microRNA encoding genes in the susceptibility to hepatocellular carcinoma: a systematic review and meta-analysis

[PMID 24301908] miR-499A>G rs3746444 and miR-146aG>C expression and hepatocellular carcinoma risk in the Chinese population

[PMID 24413317OA-icon.png] MicroRNA sequence polymorphisms and the risk of different types of cancer

[PMID 24447667] A common variant in pre-miR-146 is associated with coronary artery disease risk and its mature miRNA expression

[PMID 24502829] Has-mir-146a rs2910164 polymorphism and risk of immune thrombocytopenia

[PMID 24528016] A Genetic Variant in MiR-146a Modifies Digestive System Cancer Risk: a Meta-analysis

[PMID 24568449] Associations of Single Nucleotide Polymorphisms in miR-146a, miR-196a, miR-149 and miR-499 with Colorectal Cancer Susceptibility

[PMID 22659075] Association of the miR-146aC>G, miR-196a2C>T, and miR-499A>G polymorphisms with moyamoya disease in the Korean population.

[PMID 22711332] A single nucleotide polymorphism in microRNA-146a is associated with the risk for nasopharyngeal carcinoma.

[PMID 22846912] Genetic variants in miRNAs predict bladder cancer risk and recurrence.

[PMID 22926736] Low penetrance alleles as risk modifiers in familial and sporadic breast cancer.

[PMID 23001871] Association of the miR-146aC>G, miR-149T>C, miR-196a2T>C, and miR-499A>G polymorphisms with gastric cancer risk and survival in the Korean population.

[PMID 23020128] The miR-146a rs2910164 C/G polymorphism is associated with telangiectasia in systemic sclerosis.

[PMID 23222547] The rs2910164 G>C polymorphism in microRNA-146a is associated with the incidence of malignant melanoma.

[PMID 23292097] Effects of common polymorphisms rs2910164 in miR-146a and rs3746444 in miR-499 on cancer susceptibility: a meta-analysis.

[PMID 23292505] Association of a single-nucleotide polymorphism within the miR-146a gene with susceptibility for acute-on-chronic hepatitis B liver failure.

[PMID 23306950] A genetic variant in miR-146a modifies colorectal cancer susceptibility in a Chinese population.

[PMID 23543085] Association study of genetic variants in miRNAs in patients with inflammatory bowel disease: preliminary results.

[PMID 23593385OA-icon.png] Effects of common polymorphism rs11614913 in Hsa-miR-196a2 on lung cancer risk.

[PMID 23731641] Association of microRNAs genes polymorphisms with rheumatoid arthritis in Egyptian female patients.

[PMID 23794009] miR-146a polymorphism influences levels of miR-146a, IRAK-1, and TRAF-6 in young patients with coronary artery disease.

[PMID 24803388] Association of miR-146a polymorphisms with systemic lupus erythematosus: a meta-analysis

[PMID 24039706OA-icon.png] The associations of single nucleotide polymorphisms in miR-146a, miR-196a and miR-499 with breast cancer susceptibility

[PMID 24916311] MicroRNAs related polymorphisms and genetic susceptibility to esophageal squamous cell carcinoma

[PMID 24978643] Genetic variants of MicroRNA-related genes in susceptibility and prognosis of end-stage renal disease and renal allograft outcome among north Indians

[PMID 25053223] A micro RNA-146a polymorphism is associated with coronary restenosis

[PMID 25084752] Association between genetic variant in hsa-miR-146a gene and prostate cancer progression: evidence from Serbian population

[PMID 25154761] MicroRNA-146a rs2910164 polymorphism is associated with susceptibility to non-small cell lung cancer in the Chinese population

[PMID 25209759OA-icon.png] A single-nucleotide polymorphism of miR-146a and psoriasis: an association and functional study

[PMID 25213291] Genetic Polymorphisms in miRNAs and Susceptibility to Colorectal Cancer

[PMID 25218914] Comprehensive Review of Genetic Association Studies and Meta-analysis on miRNA polymorphisms and rheumatoid arthritis and systemic lupus erythematosus susceptibility

[PMID 24681820] Genetic variations in microRNAs and the risk and survival of renal cell cancer

[PMID 25291868] Pre-miR146a expression in follicular carcinomas of the thyroid

[PMID 25374621OA-icon.png] Common genetic variants in pre-microRNAs and risk of breast cancer in the North Indian population

[PMID 25455160] The association between miR-146a gene rs2910164 polymorphism and gastric cancer risk: A meta-analysis

[PMID 25445498] A common polymorphism in pre-miR-146a underlies Hirschsprung disease risk in Han Chinese

[PMID 25630616] Is the microRNA-146a (rs2910164) polymorphism associated with rheumatoid arthritis? Association of microRNA-146a (rs2910164) polymorphism and rheumatoid arthritis could depend on gender

[PMID 25767384OA-icon.png] Effect of a single nucleotide polymorphism in miR-146a on COX-2 protein expression and lung function in smokers with chronic obstructive pulmonary disease

[PMID 25795117] Comprehensive assessment of the association between miRNA polymorphisms and gastric cancer risk

[PMID 25891929] A functional polymorphism of the microRNA-146a gene is associated with susceptibility to drug-resistant epilepsy and seizures frequency

[PMID 25901206OA-icon.png] Influence of microRNA-related polymorphisms on clinical outcomes in coronary artery disease

[PMID 25958310] Association of MicroRNA-146a rs2910164 Gene Polymorphism with Metabolic Syndrome

[PMID 25176041OA-icon.png] High-resolution melting analysis reveals genetic polymorphisms in microRNAs confer hepatocellular carcinoma risk in Chinese patients

[PMID 26053525] Association of Pre-miRNA-499 rs3746444 and Pre-miRNA-146a rs2910164 Polymorphisms and Susceptibility to Behcet's Disease

[PMID 26114385OA-icon.png] Meta-Analysis of miR-146a Polymorphisms Association with Coronary Artery Diseases and Ischemic Stroke

[PMID 26305248OA-icon.png] Variants of MicroRNA Genes: Gender-Specific Associations with Multiple Sclerosis Risk and Severity

[PMID 26323945] Effect of a functional polymorphism in the pre-miR-146a gene on the risk and prognosis of renal cell carcinoma

[PMID 26337564] Association between a Genetic Variant in the hsa-miR-146a Gene and Cancer Risk: An Updated Meta-Analysis

[PMID 26406571] The association between two common polymorphisms (miR-146a rs2910164 and miR-196a2 rs11614913) and susceptibility to gastric cancer: A meta-analysis

[PMID 25673459OA-icon.png] Affection of single-nucleotide polymorphisms in miR-27a, miR-124a, and miR-146a on susceptibility to type 2 diabetes mellitus in Chinese Han people

[PMID 26458899OA-icon.png] Common genetic polymorphisms in pre-microRNAs and risk of bladder cancer

[PMID 26476291] Association of the microRNA-single nucleotide polymorphism rs2910164 in miR146a with sporadic breast cancer susceptibility: A case control study

[PMID 26518769] Genetic variants in miR-196a2 and miR-499 are associated with susceptibility to esophageal squamous cell carcinoma in Chinese Han population

[PMID 26537765] A Genetic Variant in Pre-miR-146a (rs2910164 C>G) Is Associated with the Decreased Risk of Acute Coronary Syndrome in a Chinese Population

[PMID 26608782OA-icon.png] Association Between Single-Nucleotide Polymorphism (SNP) in miR-146a, miR-196a2, and miR-499 and Risk of Ischemic Stroke: A Meta-Analysis.

[PMID 26896831] The correlation between miR-146a C/G polymorphism and UHRF1gene expression level in gastric tumor.

[PMID 26926727] [Interaction research on smoking and microRNA genes SNP related to lung cancer in Fujian Han population].

[PMID 27098222] Association between the three functional miR-146a single-nucleotide polymorphisms, rs2910164, rs57095329, and rs2431697, and autoimmune disease susceptibility: A meta-analysis.

[PMID 27105532OA-icon.png] Genetic variant of miR-146a rs2910164 C>G and gastric cancer susceptibility.

[PMID 27164084OA-icon.png] Association of the MicroRNA-146a SNP rs2910164 with Ischemic Stroke Incidence and Prognosis in a Chinese Population.

[PMID 27293850OA-icon.png] Effects of common polymorphisms in miR-146a and miR-196a2 on lung cancer susceptibility: a meta-analysis.

[PMID 27342690OA-icon.png] Polymorphisms in STAT4, IL10, PSORS1C1, PTPN2 and MIR146A genes are differently associated with prognostic factors in Italian patients affected by Rheumatoid Arthritis.

[PMID 27434289] Functional SNP in stem of mir-146a affect Her2 status and breast cancer survival.

[PMID 27824903OA-icon.png] miR-146a Polymorphism (rs2910164) Predicts Colorectal Cancer Patients' Susceptibility to Liver Metastasis.

[PMID 27888002] Polymorphisms in MIR499A and MIR125A gene are associated with autoimmune thyroid diseases.

[PMID 28103790OA-icon.png] MicroRNA-146a rs2910164 is associated with severe preeclampsia in Black South African women on HAART.

[PMID 26997512] A single-nucleotide polymorphism in the MicroRNA-146a gene is associated with diabetic nephropathy and sight-threatening diabetic retinopathy in Caucasian patients.

[PMID 28218896OA-icon.png] A Variant in the Precursor of MicroRNA-146a is Responsible for Development of Erectile Dysfunction in Patients with Chronic Prostatitis via Targeting NOS1.

[PMID 28467961] Detection of nasopharyngeal carcinoma susceptibility with single nucleotide polymorphism analysis using next-generation sequencing technology.

[PMID 28881764OA-icon.png] Detection of nasopharyngeal carcinoma susceptibility with single nucleotide polymorphism analysis using next-generation sequencing technology.

[PMID 28922434] Association of microRNA Polymorphisms with the Risk of Gastric Cancer in a Romanian Population.

[PMID 28950676OA-icon.png] Association between Microrna 146a and Microrna 196a2 Genes Polymorphism and Breast Cancer Risk in North Indian Women

[PMID 29715515] Contribution of microRNA-149, microRNA-146a, and microRNA-196a2 SNPs in colorectal cancer risk and clinicopathological features in Tunisia.

[PMID 29922603OA-icon.png] Association of rs3787016 in Long Non-coding RNAs POLR2E and rs2910164 in MiRNA-146a with Prostate Cancer: A Systematic Review and Meta-analysis.

[PMID 30447914] Polymorphisms in non-coding RNAs and risk of colorectal cancer: A systematic review and meta-analysis.

[PMID 30463656] [STAT4 rs7574865 polymorphism is associated with the susceptibility of rheumatoid arthritis in Wuling mountain area].

[PMID 30732186OA-icon.png] Association of rs2910164 polymorphism in MiR-146a gene with psoriasis susceptibility: A meta-analysis.

[PMID 30642347OA-icon.png] MiRNA-146a polymorphism increases the odds of malaria in pregnancy.

[PMID 30801535OA-icon.png] Analysis of 75 Candidate SNPs Associated with Acute Rejection in Kidney Transplant Recipients: Validation of rs2910164 in MicroRNA MIR146A.

[PMID 30872409OA-icon.png] Impacts of Single Nucleotide Polymorphisms in three MicroRNAs (miR-146a, miR-196a2 and miR-499) on Susceptibility to Cervical Cancer among Indian Women.

[PMID 30963551] Association of MIR146A rs2910164 variation with a predisposition to sporadic breast cancer in a Pakistani cohort.

[PMID 31918067] Impact of miR-SNP rs2910164 on miR-146a expression in osteoarthritic chondrocytes.

[PMID 32125286OA-icon.png] MicroRNA-146a regulates immune-related adverse events caused by immune checkpoint inhibitors.

[PMID 32132049] Association Between the Functional miR-146a SNP rs2910164 and Risk of Digestive System Cancer: Updated Meta-analysis.

[PMID 32142098OA-icon.png] A genetic variant in microRNA-146a is associated with sporadic breast cancer in a Southern Brazilian Population.

[PMID 32234053OA-icon.png] Comparison and development of machine learning tools for the prediction of chronic obstructive pulmonary disease in the Chinese population.

[PMID 32596945OA-icon.png] A SNP of miR-146a is involved in bladder cancer relapse by affecting the function of bladder cancer stem cells via the miR-146a signallings.

[PMID 33294082OA-icon.png] The miR-146a SNP Rs2910164 and miR-155 SNP rs767649 Are Risk Factors for Non-Small Cell Lung Cancer in the Iranian Population.