rs2981579
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | common | |
| (C;T) | 1.20x risk for breast cancer | |
| (T;T) | 1.64x risk for breast cancer |
| Reference | GRCh38 38.1/142 |
| Chromosome | 10 |
| Position | 121577821 |
| Gene | FGFR2 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs2981579 |
| dbSNP (classic) | rs2981579 |
| ClinGen | rs2981579 |
| ebi | rs2981579 |
| HLI | rs2981579 |
| Exac | rs2981579 |
| Gnomad | rs2981579 |
| Varsome | rs2981579 |
| LitVar | rs2981579 |
| Map | rs2981579 |
| PheGenI | rs2981579 |
| Biobank | rs2981579 |
| 1000 genomes | rs2981579 |
| hgdp | rs2981579 |
| ensembl | rs2981579 |
| geneview | rs2981579 |
| scholar | rs2981579 |
| rs2981579 | |
| pharmgkb | rs2981579 |
| gwascentral | rs2981579 |
| openSNP | rs2981579 |
| 23andMe | rs2981579 |
| SNPshot | rs2981579 |
| SNPdbe | rs2981579 |
| MSV3d | rs2981579 |
| GWAS Ctlg | rs2981579 |
| GMAF | 0.4853 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
This SNP is basically a proxy for SNP rs1219648, which represents the SNP in the FGFR2 gene with the strongest association with breast cancer. {Note: the alleles shown for this SNP in SNPedia are in orientation to the dbSNP entry, not as published.] [PMID 17529973
]
| GWAS snp | |
|---|---|
| PMID | [PMID 19330030]
|
| Trait | Breast cancer |
| Title | A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1) |
| Risk Allele | T |
| P-val | 2E-10 |
| Odds Ratio | |
| GWAS snp | |
|---|---|
| PMID | [PMID 20453838]
|
| Trait | Breast cancer |
| Title | Genome-wide association study identifies five new breast cancer susceptibility loci |
| Risk Allele | A |
| P-val | 4E-31 |
| Odds Ratio | 1.43 [1.35-1.53] |
[PMID 21445572] Genetic polymorphisms and breast cancer risk: evidence from meta-analyses, pooled analyses, and genome-wide association studies
[PMID 18285324] Common variation in the fibroblast growth factor receptor 2 gene is not associated with endometriosis risk.
[PMID 18326623] Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33.
[PMID 19497954] Histone-acetylated control of fibroblast growth factor receptor 2 intron 2 polymorphisms and isoform splicing in breast cancer.
[PMID 19500394] Genetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses' Health Study.
[PMID 20554749] FGFR2 and other loci identified in genome-wide association studies are associated with breast cancer in African-American and younger women.
[PMID 22160591] A genetic risk predictor for breast cancer using a combination of low-penetrance polymorphisms in a Japanese population.
| GWAS snp | |
|---|---|
| PMID | [PMID 23535729]
|
| Trait | Breast cancer |
| Title | Large-scale genotyping identifies 41 new loci associated with breast cancer risk. |
| Risk Allele | A |
| P-val | 2E-170 |
| Odds Ratio | 1.27 [1.24-1.29] |
[PMID 24454457] Case-control study on the fibroblast growth factor receptor 2 gene polymorphisms associated with breast cancer in chinese han women
[PMID 22965832] Association of common genetic variants with breast cancer risk and clinicopathological characteristics in a Chinese population.
[PMID 23124475] Three novel functional polymorphisms in the promoter of FGFR2 gene and breast cancer risk: a HuGE review and meta-analysis.
[PMID 26175953] FGFR2 gene polymorphisms are associated with breast cancer risk in the Han Chinese population
[PMID 32366738] Low-penetrance susceptibility variants and postmenopausal oestrogen receptor positive breast cancer.
