rs3018362 increases susceptibility to Osteoporotic fractures for carriers of the A allele [PMID 18445777]
related to Paget’s disease of bone 23andMe blog.
| GWAS snp
|
| PMID
|
[PMID 20436471 ]
|
| Trait
|
Paget's disease
|
| Title
|
Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone
|
| Risk Allele
|
A
|
| P-val
|
5E-13
|
| Odds Ratio
|
1.52 [1.36-1.70]
|
| GWAS snp
|
| PMID
|
[PMID 21623375]
|
| Trait
|
|
| Title
|
Genome-wide association identifies three new susceptibility loci for Paget's disease of bone.
|
| Risk Allele
|
A
|
| P-val
|
8E-21
|
| Odds Ratio
|
1.4500 [1.34-1.56]
|
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[PMID 20534768] OPG and RANK polymorphisms are both associated with cortical bone mineral density: findings from a metaanalysis of the Avon longitudinal study of parents and children and gothenburg osteoporosis and obesity determinants cohorts.
[PMID 20554715] Analysis of recently identified osteoporosis susceptibility genes in Han Chinese women.
[PMID 23531404] Association of genetic polymorphisms of RANK, RANKL and OPG with bone mineral density in Chinese peri- and postmenopausal women.
[PMID 24921058] Receptor activator of nuclear factor kappa-B gene polymorphisms in Iranian periodontitis and peri-implantitis patients
[PMID 25464125] RANK/RANKL/OPG pathway: genetic associations with stress fracture period prevalence in elite athletes
]
