rs314276

Orientation

plus

Stabilized

plus

Make rs314276(A;A)

Make rs314276(A;C)

Make rs314276(C;C)

Reference

GRCh38 38.1/141

Chromosome

6

Position

104960124

Gene

LIN28B

is a	snp
is	mentioned by
dbSNP	rs314276
dbSNP (classic)	rs314276
ClinGen	rs314276
ebi	rs314276
HLI	rs314276
Exac	rs314276
Gnomad	rs314276
Varsome	rs314276
LitVar	rs314276
Map	rs314276
PheGenI	rs314276
Biobank	rs314276
1000 genomes	rs314276
hgdp	rs314276
ensembl	rs314276
geneview	rs314276
scholar	rs314276
google	rs314276
pharmgkb	rs314276
gwascentral	rs314276
openSNP	rs314276
23andMe	rs314276
SNPshot	rs314276
SNPdbe	rs314276
MSV3d	rs314276
GWAS Ctlg	rs314276

GMAF

0.3641

Max Magnitude

0

?	(A;A) (A;C) (C;C)	28

23andMe blog

rs314276 or the equivalent rs314263(T) yields

• Female
  • menarche about six weeks earlier
  • 1.2x accelerated breast development and a faster rate of increase in height and weight.
  • a reduction in adult height of about 0.15 inches.
• Male
  • 1.26 greater odds of advanced voice breaking at age 15
  • 1.19 times greater odds of advanced pubic hair at age 13
  • faster rate of growth at age 10 and about a tenth of an inch less in adult height.

GWAS snp
PMID	[PMID 19448623]
Trait	Menarche (age at onset)
Title	Genetic variation in LIN28B is associated with the timing of puberty
Risk Allele	C
P-val	4E-16
Odds Ratio	0.14 [0.11-0.17] years younger

OMIM	612882
Desc
Variant
Related	also

[PMID 20962026] Associations between the Pubertal Timing-Related Variant in LIN28B and BMI Vary Across the Life Course

[PMID 22822098] Functional Study of Risk Loci of Stem Cell-associated Gene Lin-28B and Associations with Disease Survival Outcomes in Epithelial Ovarian Cancer

GWAS snp
PMID	[PMID 24770850]
Trait	Puberty onset
Title	Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty.
Risk Allele	C
P-val	2E-8
Odds Ratio	.08 [0.053-0.107] unit increase