rs35337543

minus

Geno	Mag	Summary
(C;G)	1.5	Somewhat reduced risk for developing hypothyroidism
(G;G)	0	common in complete genomics

Make rs35337543(C;C)

Reference

GRCh38 38.1/142

Chromosome

2

Position

162279995

Gene

IFIH1

is a	snp
is	mentioned by
dbSNP	rs35337543
dbSNP (classic)	rs35337543
ClinGen	rs35337543
ebi	rs35337543
HLI	rs35337543
Exac	rs35337543
Gnomad	rs35337543
Varsome	rs35337543
LitVar	rs35337543
Map	rs35337543
PheGenI	rs35337543
Biobank	rs35337543
1000 genomes	rs35337543
hgdp	rs35337543
ensembl	rs35337543
geneview	rs35337543
scholar	rs35337543
google	rs35337543
pharmgkb	rs35337543
gwascentral	rs35337543
openSNP	rs35337543
23andMe	rs35337543
SNPshot	rs35337543
SNPdbe	rs35337543
MSV3d	rs35337543
GWAS Ctlg	rs35337543

GMAF

0.007346

Max Magnitude

1.5

rs35337543, also known as c.1641+1G>C, represents a variant in the IFIH1 gene on chromosome 2.

Based on a study of UK BioBank participants, carriers of a rs35337543(C) allele are reported to be at reduced risk of developing hypothyroidism (OR 0.77, CI:0.70-0.85, p=5×10e−9).([PMID 29691411 ]

[PMID 22110759 ] Polymorphisms in the Innate Immune IFIH1 Gene, Frequency of Enterovirus in Monthly Fecal Samples during Infancy, and Islet Autoimmunity

[PMID 19961590 ] The rs1990760 polymorphism within the IFIH1 locus is not associated with Graves' disease, Hashimoto's thyroiditis and Addison's disease.

[PMID 23144876 ] Enterovirus RNA in Peripheral Blood May Be Associated with the Variants of rs1990760, a Common Type 1 Diabetes Associated Polymorphism in IFIH1

ClinVar
Risk	rs35337543(A;A) rs35337543(C;C)
Alt	rs35337543(A;A) rs35337543(C;C)
Reference	Rs35337543(G;G)
Significance	Non-pathogenic
Disease	not specified
Variation	info
Gene	IFIH1
CLNDBN	not specified
Reversed	1
HGVS	NC_000002.11:g.163136505C>G
CLNSRC
CLNACC	RCV000245122.1,