rs356165
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (G;G) | 0 | common in clinvar |
| Make rs356165(A;A) |
| Make rs356165(A;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 4 |
| Position | 89725735 |
| Gene | SNCA |
| is a | snp |
| is | mentioned by |
| dbSNP | rs356165 |
| dbSNP (classic) | rs356165 |
| ClinGen | rs356165 |
| ebi | rs356165 |
| HLI | rs356165 |
| Exac | rs356165 |
| Gnomad | rs356165 |
| Varsome | rs356165 |
| LitVar | rs356165 |
| Map | rs356165 |
| PheGenI | rs356165 |
| Biobank | rs356165 |
| 1000 genomes | rs356165 |
| hgdp | rs356165 |
| ensembl | rs356165 |
| geneview | rs356165 |
| scholar | rs356165 |
| rs356165 | |
| pharmgkb | rs356165 |
| gwascentral | rs356165 |
| openSNP | rs356165 |
| 23andMe | rs356165 |
| SNPshot | rs356165 |
| SNPdbe | rs356165 |
| MSV3d | rs356165 |
| GWAS Ctlg | rs356165 |
| GMAF | 0.4885 |
| Max Magnitude | 0 |
rs356165 is a SNP in the 3' UTR of the alpha-synuclein SNCA gene. It has been associated in some studies, and not others, with Parkinson's disease.
[PMID 20478361] A study of 330 Chinese with Parkinson's found no association with rs356165 and risk for Parkinson's.
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
[PMID 18485051] Multiple alpha-synuclein gene polymorphisms are associated with Parkinson's disease in a Norwegian population.
[PMID 22076805] A Search for SNCA 3' UTR Variants Identified SNP rs356165 as a Determinant of Disease Risk and Onset Age in Parkinson's Disease
[PMID 22451204
] Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2
[PMID 15637659] Linkage disequilibrium patterns and tagSNP transferability among European populations.
[PMID 17531291] Familial genes in sporadic disease: common variants of alpha-synuclein gene associate with Parkinson's disease.
[PMID 17872362] alpha-Synuclein and Parkinson disease susceptibility.
[PMID 19063963] Genetic susceptibility in Parkinson's disease.
[PMID 19771175] Genetic variants of the alpha-synuclein gene SNCA are associated with multiple system atrophy.
[PMID 19890971] Alpha-synuclein polymorphisms are associated with Parkinson's disease in a Saskatchewan population.
[PMID 22291217] An evaluation of the impact of MAPT, SNCA and APOE on the burden of Alzheimer's and Lewy body pathology.
| ClinVar | |
|---|---|
| Risk | rs356165(A;A) |
| Alt | rs356165(A;A) |
| Reference | Rs356165(G;G) |
| Significance | Non-pathogenic |
| Disease | Parkinson Disease |
| Variation | info |
| Gene | SNCA |
| CLNDBN | Parkinson Disease, Dominant |
| Reversed | 0 |
| HGVS | NC_000004.11:g.90646886G>A |
| CLNSRC | |
| CLNACC | RCV000360597.1, |
[PMID 30410434] A Comprehensive Analysis of the Association Between SNCA Polymorphisms and the Risk of Parkinson's Disease.
