rs35742686

minus

Geno	Mag	Summary
(-;-)		CYP2D6*3 homozygote
(-;A)		carrier of one CYP2D6*3 allele
(A;A)	0	normal

Reference

GRCh38 38.1/142

Chromosome

22

Position

42128242

Gene	CYP2D6, LOC102723722, LOC107987465, LOC107987481

is a	snp
is	mentioned by
dbSNP	rs35742686
dbSNP (classic)	rs35742686
ClinGen	rs35742686
ebi	rs35742686
HLI	rs35742686
Exac	rs35742686
Gnomad	rs35742686
Varsome	rs35742686
LitVar	rs35742686
Map	rs35742686
PheGenI	rs35742686
Biobank	rs35742686
1000 genomes	rs35742686
hgdp	rs35742686
ensembl	rs35742686
geneview	rs35742686
scholar	rs35742686
google	rs35742686
pharmgkb	rs35742686
gwascentral	rs35742686
openSNP	rs35742686
23andMe	rs35742686
SNPshot	rs35742686
SNPdbe	rs35742686
MSV3d	rs35742686
GWAS Ctlg	rs35742686

GMAF

0.009183

Max Magnitude

0

rs35742686, which is also known as 2549delA, is a SNP in the CYP2D6 gene.

The rs35742686(-) allele defines the CYP2D6*3 variant, which is inactive. [PMID 23130019 ] Frequencies of 23 functionally significant variant alleles related with metabolism of antineoplastic drugs in the chilean population: comparison with caucasian and asian populations.

[PMID 23133420 ] Pharmacogenomic Diversity among Brazilians: Influence of Ancestry, Self-Reported Color, and Geographical Origin.

ClinVar
Risk	Rs35742686(-;-)
Alt	Rs35742686(-;-)
Reference	Rs35742686(A;A)
Significance	Drug-response
Disease	Debrisoquine
Variation	info
Gene	CYP2D6
CLNDBN	Debrisoquine, poor metabolism of
Reversed	1
HGVS	NC_000022.10:g.42524244delT
CLNSRC	OMIM Allelic Variant
CLNACC	RCV000018390.25,