rs368234815

Orientation

plus

Stabilized

plus

Geno	Mag	Summary
(TT;TT)	0	common in clinvar

Make rs368234815(G;G)

Make rs368234815(G;TT)

Reference

GRCh38.p2 38.2/144

Chromosome

19

Position

39248514

Gene

IFNL4

is a	snp
is	mentioned by
dbSNP	rs368234815
dbSNP (classic)	rs368234815
ClinGen	rs368234815
ebi	rs368234815
HLI	rs368234815
Exac	rs368234815
Gnomad	rs368234815
Varsome	rs368234815
LitVar	rs368234815
Map	rs368234815
PheGenI	rs368234815
Biobank	rs368234815
1000 genomes	rs368234815
hgdp	rs368234815
ensembl	rs368234815
geneview	rs368234815
scholar	rs368234815
google	rs368234815
pharmgkb	rs368234815
gwascentral	rs368234815
openSNP	rs368234815
23andMe	rs368234815
SNPshot	rs368234815
SNPdbe	rs368234815
MSV3d	rs368234815
GWAS Ctlg	rs368234815

Max Magnitude

0

[PMID 26186989] Comparison of Functional Variants in IFNL4 and IFNL3 for Association with Hepatitis C Virus Clearance

[PMID 26372394] IFNL4 rs368234815 polymorphism is associated with innate resistance to HIV-1 infection

[PMID 26406534] IFN lambda 4 genotypes and resistance-associated variants in HCV genotype 1 and 3 infected patients

[PMID 25577150] Interferon-λ4 is a cell-autonomous type III interferon associated with pre-treatment hepatitis C virus burden

ClinVar
Risk	rs368234815(G;G)
Alt	rs368234815(G;G)
Reference	Rs368234815(TT;TT)
Significance	Drug-response
Disease	peginterferon alfa-2a
Variation	info
Gene	IFNL4
CLNDBN	peginterferon alfa-2a, peginterferon alfa-2b, ribavirin, and telaprevir response - Efficacy
Reversed	0
HGVS	NC_000019.9:g.39739154_39739155delTTinsG
CLNSRC	PharmGKB Clinical Annotation
CLNACC	RCV000211132.1,

[PMID 28394349] IFN-λ3, not IFN-λ4, likely mediates IFNL3-IFNL4 haplotype-dependent hepatic inflammation and fibrosis.

[PMID 29055988] [Association of HLA-DQ and IFNL4 polymorphisms with hepatitis B virus infection and clearance].