rs3745516

Orientation

plus

Stabilized

plus

Geno	Mag	Summary
(A;A)	2	Increased risk of developing primary biliary cirrhosis
(A;G)	1.5	Slightly increased risk of developing primary biliary cirrhosis
(G;G)	1	Normal risk of developing primary biliary cirrhosis

Reference

GRCh38 38.1/141

Chromosome

19

Position

50423485

Gene

SPIB

is a	snp
is	mentioned by
dbSNP	rs3745516
dbSNP (classic)	rs3745516
ClinGen	rs3745516
ebi	rs3745516
HLI	rs3745516
Exac	rs3745516
Gnomad	rs3745516
Varsome	rs3745516
LitVar	rs3745516
Map	rs3745516
PheGenI	rs3745516
Biobank	rs3745516
1000 genomes	rs3745516
hgdp	rs3745516
ensembl	rs3745516
geneview	rs3745516
scholar	rs3745516
google	rs3745516
pharmgkb	rs3745516
gwascentral	rs3745516
openSNP	rs3745516
23andMe	rs3745516
SNPshot	rs3745516
SNPdbe	rs3745516
MSV3d	rs3745516
GWAS Ctlg	rs3745516

GMAF

0.4968

Max Magnitude

2

?	(A;A) (A;G) (G;G)	28

GWAS snp
PMID	[PMID 20639880]
Trait	Primary biliary cirrhosis
Title	Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis
Risk Allele	A
P-val	8E-11
Odds Ratio	1.46 [NR]

Each A allele of this SNP in the SPIB gene is associated with 1.46 times higher odds of primary biliary cirrhosis. [PMID 20639880]

GWAS snp
PMID	[PMID 21399635]
Trait
Title	Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis
Risk Allele	A
P-val	2E-13
Odds Ratio	1.3800 [1.32-1.44]

[PMID 20639879] Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis.

[PMID 21506939] Replicated association of 17q12-21 with susceptibility of primary biliary cirrhosis in a Japanese cohort.