rs3802177

Orientation

minus

Stabilized

minus

Geno	Mag	Summary
(C;C)		1.16x increased risk for type-2 diabetes
(C;T)		1.16x increased risk for type-2 diabetes
(T;T)	0	normal

Reference

GRCh38 38.1/141

Chromosome

8

Position

117172786

Gene	LOC105375716, SLC30A8

is a	snp
is	mentioned by
dbSNP	rs3802177
dbSNP (classic)	rs3802177
ClinGen	rs3802177
ebi	rs3802177
HLI	rs3802177
Exac	rs3802177
Gnomad	rs3802177
Varsome	rs3802177
LitVar	rs3802177
Map	rs3802177
PheGenI	rs3802177
Biobank	rs3802177
1000 genomes	rs3802177
hgdp	rs3802177
ensembl	rs3802177
geneview	rs3802177
scholar	rs3802177
google	rs3802177
pharmgkb	rs3802177
gwascentral	rs3802177
openSNP	rs3802177
23andMe	rs3802177
SNPshot	rs3802177
SNPdbe	rs3802177
MSV3d	rs3802177
GWAS Ctlg	rs3802177

GMAF

0.2833

Max Magnitude

0

?	(C;C) (C;T) (T;T)	28

[PMID 18477659] rs3802177 replicated as significant for type-2 diabetes risk in 1,900 Japanese patients, with odds ratio of 1.16 (CI: 1.05-1.27, p = 4.5 x 10e-3)

Note: this SNP is fairly tightly linked (r² = 0.83) to another SNP in the SLC30A8 gene also linked to type-2 diabetes, rs13266634

GWAS snp
PMID	[PMID 20581827]
Trait	Type 2 diabetes
Title	Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
Risk Allele	G
P-val	1E-8
Odds Ratio	1.15 [1.10-1.21]

[PMID 18469204] Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians.

[PMID 20550665] Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population.

[PMID 20554072] Gestational diabetes mellitus screening based on the gene chip technique.

GWAS snp
PMID	[PMID 22693455]
Trait
Title	Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.
Risk Allele	G
P-val	4E-8
Odds Ratio	1.2300 None

GWAS snp
PMID	[PMID 24509480]
Trait	Type 2 diabetes
Title	Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
Risk Allele	G
P-val	2E-18
Odds Ratio	1.16 [1.11-1.22]