|(T;T)||3||1.6x increased risk for breast cancer|
In a study of 1,267 breast cancer patients, rs3803662 heterozygote carriers and minor allele homozygote carriers were more likely to be diagnosed before the age of 60 years (p = 0.025) relative to major allele homozygote carriers.[PMID 17997823]
- rs2981582, rs3803662, and rs889312) showed weak but significant associations with ER-negative disease, the strongest association being for rs3803662 in TNRC9 (1.14 (1.09-1.21))
[PMID 19005751] rs3803662 confirmed in 988 sporadic breast cancer cases and 1,016 controls from the West of Ireland to be associated with increased risk (odds ratio 1.15, p(allelic) = 5.1 x 10e-2) for breast cancer
|Title||A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)|
[PMID 20406955] Polymorphisms in the TOX3/LOC643714 Locus and Risk of Breast Cancer in African-American Women
|Title||Genome-wide association study identifies five new breast cancer susceptibility loci|
|Odds Ratio||1.30 [1.22-1.39]|
[PMID 20664043] Incidence of breast cancer and its subtypes in relation to individual and multiple low-penetrance genetic susceptibility loci
[PMID 20054709] Birth weight, breast cancer susceptibility loci, and breast cancer risk
[PMID 20699374] Evaluation of Breast Cancer Susceptibility Loci in Chinese Women
[PMID 20703937] Association between polymorphisms of trinucleotide repeat containing 9 gene and breast cancer risk: evidence from 62,005 subjects
|Title||A combined analysis of genome-wide association studies in breast cancer|
|Odds Ratio||1.22 [1.13-1.32]|
[PMID 21197568] Risk of genome-wide association study newly identified genetic variants for breast cancer in Chinese women of Heilongjiang Province
[PMID 21415360] Common genetic variants associated with breast cancer in Korean women and differential susceptibility according to intrinsic subtype
[PMID 21445572] Genetic polymorphisms and breast cancer risk: evidence from meta-analyses, pooled analyses, and genome-wide association studies
[PMID 21475998] Replication of five GWAS-identified loci and breast cancer risk among Hispanic and non-Hispanic white women living in the Southwestern United States
[PMID 21748294] Correlation of breast cancer susceptibility loci with patient characteristics, metastasis-free survival, and mRNA expression of the nearest genes
[PMID 21791674] Interactions Between Genetic Variants and Breast Cancer Risk Factors in the Breast and Prostate Cancer Cohort Consortium
[PMID 21795501] Replication of breast cancer GWAS susceptibility loci in the Women's Health Initiative African American SHARe study
[PMID 21996731] Breast cancer genome-wide association studies: there is strength in numbers
[PMID 22452962] A genome-wide association study identifies a breast cancer risk variant in ERBB4 at 2q34: results from the Seoul Breast Cancer Study
[PMID 18326623] Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33.
[PMID 18612136] Discriminatory accuracy from single-nucleotide polymorphisms in models to predict breast cancer risk.
[PMID 18681954] Breast cancer susceptibility loci and mammographic density.
[PMID 18708391] Breast cancer risk polymorphisms and interaction with ionizing radiation among U.S. radiologic technologists.
[PMID 18772892] Can genes for mammographic density inform cancer aetiology?
[PMID 18785201] Novel breast cancer risk alleles and endometrial cancer risk.
[PMID 18973230] Breast cancer susceptibility alleles and ovarian cancer risk in 2 study populations.
[PMID 19088016] Genetic susceptibility loci for breast cancer by estrogen receptor status.
[PMID 19094228] The influence of genetic variation in 30 selected genes on the clinical characteristics of early onset breast cancer.
[PMID 19219042] Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1.
[PMID 19232126] Association between breast cancer susceptibility loci and mammographic density: the Multiethnic Cohort.
[PMID 19304784] Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study.
[PMID 19454617] Genetic variation in the chromosome 17q23 amplicon and breast cancer risk.
[PMID 19567422] Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042.
[PMID 19931039] Using lifetime risk estimates in personal genomic profiles: estimation of uncertainty.
[PMID 20085711] Leveraging genetic variability across populations for the identification of causal variants.
[PMID 20146796] Familial relative risks for breast cancer by pathological subtype: a population-based cohort study.
[PMID 20213080] Genetic variants in trinucleotide repeat-containing 9 (TNRC9) are associated with risk of estrogen receptor positive breast cancer in a Chinese population.
[PMID 20237344] Performance of common genetic variants in breast-cancer risk models.
[PMID 20484103] Genetic and clinical predictors for breast cancer risk assessment and stratification among Chinese women.
[PMID 20585626] Identification of a functional genetic variant at 16q12.1 for breast cancer risk: results from the Asia Breast Cancer Consortium.
[PMID 20605201] Gene-environment interactions in 7610 women with breast cancer: prospective evidence from the Million Women Study.
[PMID 21475997] Association between rs3803662 polymorphism of trinucleotide repeat containing 9 gene and breast cancer risk.
[PMID 21596841] Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium.
[PMID 21844186] Common breast cancer susceptibility loci are associated with triple-negative breast cancer.
[PMID 22045194] Combined effect of low-penetrant SNPs on breast cancer risk.
[PMID 22160591] A genetic risk predictor for breast cancer using a combination of low-penetrance polymorphisms in a Japanese population.
[PMID 22532573] The role of genetic breast cancer susceptibility variants as prognostic factors.
[PMID 23270421] The risk allele of SNP rs3803662 and the mRNA level of its closest genes TOX3 and LOC643714 predict adverse outcome for breast cancer patients
|Trait||Breast cancer (male)|
|Title||Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk.|
|Odds Ratio||1.50 [1.35-1.66]|
[PMID 23486537] Comparison of genetic variation of breast cancer susceptibility genes in Chinese and German populations
[PMID 23717390] Identification of a Breast Cancer Susceptibility Locus at 4q31.22 Using a Genome-Wide Association Study Paradigm
[PMID 24289300] Effects of lifestyle and single nucleotide polymorphisms on breast cancer risk: a case--control study in Japanese women
|Title||Genome-wide association studies identify four ER negative-specific breast cancer risk loci.|
|Odds Ratio||1.14 [1.10-1.18]|
|Title||Large-scale genotyping identifies 41 new loci associated with breast cancer risk.|
|Odds Ratio||1.24 [1.21-1.27]|
[PMID 22910930] Genome-Wide Association Studies (GWAS) breast cancer susceptibility loci in Arabs: susceptibility and prognostic implications in Tunisians.
[PMID 23577780] Associations between single-nucleotide polymorphisms and epidural ropivacaine consumption in patients undergoing breast cancer surgery.
|Title||Genome-wide association study of breast cancer in the Japanese population.|
|Odds Ratio||1.21 [1.146-1.284]|
[PMID 25139936] Association of Cancer Susceptibility Variants with Risk of Multiple Primary Cancers: the Population Architecture using Genomics and Epidemiology Study
[PMID 24532140] Association of genetic variants at TOX3, 2q35 and 8q24 with the risk of familial and early-onset breast cancer in a South-American population
[PMID 25784121] Associations between breast density and a panel of single nucleotide polymorphisms linked to breast cancer risk: a cohort study with digital mammography
[PMID 25881232] Associations between breast density and a panel of single nucleotide polymorphisms linked to breast cancer risk: a cohort study with digital mammography
[PMID 26070784] Genetic risk variants associated with in situ breast cancer
[PMID 26711978] [Associations between TOX3 rs3803662 polymorphisms and immunological markers of breast cancer].
[PMID 26911390] TNRC9 rs12443621 and FGFR2 rs2981582 polymorphisms and breast cancer risk.
[PMID 27572905] Genetic variants in FGFR2 and TNRC9 genes are associated with breast cancer risk in Pakistani women.
[PMID 28757652] Genetic Breast Cancer Susceptibility Variants and Prognosis in the Prospectively Randomized SUCCESS A Study.
[PMID 29683073] Polymorphisms in the TOX3/LOC643714 and risk of breast cancer in south China.
[PMID 30515698] Significant association of TOX3/LOC643714 locus-rs3803662 and breast cancer risk in a cohort of Iranian population.