rs3817198
| Orientation | plus |
| Stabilized | plus |
| Make rs3817198(C;C) |
| Make rs3817198(C;T) |
| Make rs3817198(T;T) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 11 |
| Position | 1887776 |
| Gene | LSP1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs3817198 |
| dbSNP (classic) | rs3817198 |
| ClinGen | rs3817198 |
| ebi | rs3817198 |
| HLI | rs3817198 |
| Exac | rs3817198 |
| Gnomad | rs3817198 |
| Varsome | rs3817198 |
| LitVar | rs3817198 |
| Map | rs3817198 |
| PheGenI | rs3817198 |
| Biobank | rs3817198 |
| 1000 genomes | rs3817198 |
| hgdp | rs3817198 |
| ensembl | rs3817198 |
| geneview | rs3817198 |
| scholar | rs3817198 |
| rs3817198 | |
| pharmgkb | rs3817198 |
| gwascentral | rs3817198 |
| openSNP | rs3817198 |
| 23andMe | rs3817198 |
| SNPshot | rs3817198 |
| SNPdbe | rs3817198 |
| MSV3d | rs3817198 |
| GWAS Ctlg | rs3817198 |
| GMAF | 0.2084 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
| GWAS | |
|---|---|
| SNP | rs3817198 |
| PubMedID | [PMID 17529967 ]
|
| Condition | Breast cancer |
| Gene | LSP1 |
| Risk Allele | T |
| pValue | 3.00E-009 |
| OR | 1.07 |
| 95% CI | 1.04-1.11 |
rs3817198 is a SNP in the LSP1 gene on chromosome 11. The less frequent allele rs3817198(C) increases risk of breast cancer by about +10% in Caucasians, but actually may be protective in women of African ancestry.[PMID 19656774][PMID 22357627]
[PMID 17529967] rs3817198, a SNP associated with the LSP1 gene, was one of the four strongest associating SNPs found in a genome-wide association study of over 4,000 breast cancer samples.
[PMID 19656774] Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers
[PMID 20145138] Common genetic variants associated with breast cancer and mammographic density measures that predict disease
[PMID 20054709] Birth weight, breast cancer susceptibility loci, and breast cancer risk
[PMID 20699374] Evaluation of Breast Cancer Susceptibility Loci in Chinese Women
[PMID 21127985] Association of a LSP1 gene rs3817198T>C polymorphism with breast cancer risk: evidence from 33,920 cases and 35,671 controls
[PMID 21197568] Risk of genome-wide association study newly identified genetic variants for breast cancer in Chinese women of Heilongjiang Province
[PMID 21445572] Genetic polymorphisms and breast cancer risk: evidence from meta-analyses, pooled analyses, and genome-wide association studies
[PMID 21791674] Interactions Between Genetic Variants and Breast Cancer Risk Factors in the Breast and Prostate Cancer Cohort Consortium
[PMID 22357627] Evaluation of 19 Susceptibility Loci of Breast Cancer in Women of African Ancestry
[PMID 17997823] Clinical correlates of low-risk variants in FGFR2, TNRC9, MAP3K1, LSP1 and 8q24 in a Dutch cohort of incident breast cancer cases.
[PMID 18224312] Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.
[PMID 18326623] Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33.
[PMID 18437204] Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics.
[PMID 18612136] Discriminatory accuracy from single-nucleotide polymorphisms in models to predict breast cancer risk.
[PMID 18681954] Breast cancer susceptibility loci and mammographic density.
[PMID 18708391] Breast cancer risk polymorphisms and interaction with ionizing radiation among U.S. radiologic technologists.
[PMID 18772892] Can genes for mammographic density inform cancer aetiology?
[PMID 18785201] Novel breast cancer risk alleles and endometrial cancer risk.
[PMID 18973230] Breast cancer susceptibility alleles and ovarian cancer risk in 2 study populations.
[PMID 19088016] Genetic susceptibility loci for breast cancer by estrogen receptor status.
[PMID 19219042] Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1.
[PMID 19232126] Association between breast cancer susceptibility loci and mammographic density: the Multiethnic Cohort.
[PMID 19304784] Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study.
[PMID 19330030] A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1).
[PMID 19543528] Association between common germline genetic variation in 94 candidate genes or regions and risks of invasive epithelial ovarian cancer.
[PMID 19567422] Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042.
[PMID 19639606] Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases.
[PMID 19931039] Using lifetime risk estimates in personal genomic profiles: estimation of uncertainty.
[PMID 20085711] Leveraging genetic variability across populations for the identification of causal variants.
[PMID 20146796] Familial relative risks for breast cancer by pathological subtype: a population-based cohort study.
[PMID 20237344] Performance of common genetic variants in breast-cancer risk models.
[PMID 20484103] Genetic and clinical predictors for breast cancer risk assessment and stratification among Chinese women.
[PMID 20605201] Gene-environment interactions in 7610 women with breast cancer: prospective evidence from the Million Women Study.
[PMID 21596841] Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium.
[PMID 22045194] Combined effect of low-penetrant SNPs on breast cancer risk.
[PMID 22454379] Common Breast Cancer Susceptibility Variants in LSP1 and RAD51L1 Are Associated with Mammographic Density Measures that Predict Breast Cancer Risk.
[PMID 22532573] The role of genetic breast cancer susceptibility variants as prognostic factors.
[PMID 23756864] Estimating single nucleotide polymorphism associations using pedigree data: applications to breast cancer
| GWAS snp | |
|---|---|
| PMID | [PMID 23535729]
|
| Trait | Breast cancer |
| Title | Large-scale genotyping identifies 41 new loci associated with breast cancer risk. |
| Risk Allele | C |
| P-val | 2E-11 |
| Odds Ratio | 1.07 [1.05-1.09] |
[PMID 22910930] Genome-Wide Association Studies (GWAS) breast cancer susceptibility loci in Arabs: susceptibility and prognostic implications in Tunisians.
[PMID 23577780] Associations between single-nucleotide polymorphisms and epidural ropivacaine consumption in patients undergoing breast cancer surgery.
[PMID 25784121] Associations between breast density and a panel of single nucleotide polymorphisms linked to breast cancer risk: a cohort study with digital mammography
[PMID 25881232] Associations between breast density and a panel of single nucleotide polymorphisms linked to breast cancer risk: a cohort study with digital mammography
[PMID 26275715] A comprehensive evaluation of interaction between genetic variants and use of menopausal hormone therapy on mammographic density
[PMID 26911390] TNRC9 rs12443621 and FGFR2 rs2981582 polymorphisms and breast cancer risk.
[PMID 28757652] Genetic Breast Cancer Susceptibility Variants and Prognosis in the Prospectively Randomized SUCCESS A Study.
[PMID 32366738] Low-penetrance susceptibility variants and postmenopausal oestrogen receptor positive breast cancer.
