rs4149056(C;C)
From SNPedia
| 17x myopathy risk for statin users |
| Is a | genotype |
| of | rs4149056 |
| Gene | SLCO1B1 |
| Chromosome | 12 |
| Position | 21,178,615 |
| mentioned | by |
| Magnitude | 3.2 |
| Repute | Bad |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 3.2 | 17x myopathy risk for statin users |
| (C;T) | 2.1 | reduced breakdown of some drugs; 5x increased myopathy risk for statin users |
| (T;T) | 0 | normal |
reduced breakdown of some drugs;
CPIC Recommendation: Prescribe a lower dose (20mg daily) or consider an alternative statin (e.g., pravastatin or rosuvastatin); consider routine creatine kinase (CK) surveillance.
significantly associated with myopathy in patients who received simvastatin, but not in patients who received atorvastatin. [PMID 21243006]
[PMID 21851379] however it did not affect pravastatin.
