rs4406273
From SNPedia
| Orientation | plus |
| Stabilized | plus |
| Make rs4406273(A;A) |
| Make rs4406273(A;G) |
| Make rs4406273(G;G) |
| Reference | GRCh38 38.1/142 |
| Chromosome | 6 |
| Position | 31298313 |
| Gene | LOC105375015 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs4406273 |
| dbSNP (classic) | rs4406273 |
| ClinGen | rs4406273 |
| ebi | rs4406273 |
| HLI | rs4406273 |
| Exac | rs4406273 |
| Gnomad | rs4406273 |
| Varsome | rs4406273 |
| LitVar | rs4406273 |
| Map | rs4406273 |
| PheGenI | rs4406273 |
| Biobank | rs4406273 |
| 1000 genomes | rs4406273 |
| hgdp | rs4406273 |
| ensembl | rs4406273 |
| geneview | rs4406273 |
| scholar | rs4406273 |
| rs4406273 | |
| pharmgkb | rs4406273 |
| gwascentral | rs4406273 |
| openSNP | rs4406273 |
| 23andMe | rs4406273 |
| SNPshot | rs4406273 |
| SNPdbe | rs4406273 |
| MSV3d | rs4406273 |
| GWAS Ctlg | rs4406273 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs4406273 is located about 28Kb centromeric of HLA-C on human chromosome 6, and as tested in at least three populations (from Europe, Pakistan and Thailand) it is an almost perfect (95%-99%) proxy for the HLA-C*06:02 MHC allele associated with psoriasis. The rs4406273(A) allele is the HLA-C*06:02 surrogate.10.1038/jid.2014.517
[PMID 33297781] HLA-Cw6 and other HLA-C alleles, as well as MICB-DT, DDX58 and TYK2 genetic variants associate with optimal response to anti-IL-17A treatment in patients with psoriasis.
