rs4506565
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 0 | common/normal |
| (A;T) | 1.5 | 1.4x increased risk for type-2 diabetes |
| (T;T) | 2 | 1.9x increased risk for type-2 diabetes |
| Reference | GRCh38 38.1/142 |
| Chromosome | 10 |
| Position | 112996282 |
| Gene | TCF7L2 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs4506565 |
| dbSNP (classic) | rs4506565 |
| ClinGen | rs4506565 |
| ebi | rs4506565 |
| HLI | rs4506565 |
| Exac | rs4506565 |
| Gnomad | rs4506565 |
| Varsome | rs4506565 |
| LitVar | rs4506565 |
| Map | rs4506565 |
| PheGenI | rs4506565 |
| Biobank | rs4506565 |
| 1000 genomes | rs4506565 |
| hgdp | rs4506565 |
| ensembl | rs4506565 |
| geneview | rs4506565 |
| scholar | rs4506565 |
| rs4506565 | |
| pharmgkb | rs4506565 |
| gwascentral | rs4506565 |
| openSNP | rs4506565 |
| 23andMe | rs4506565 |
| SNPshot | rs4506565 |
| SNPdbe | rs4506565 |
| MSV3d | rs4506565 |
| GWAS Ctlg | rs4506565 |
| GMAF | 0.2681 |
| Max Magnitude | 2 |
| ? | (A;A) (A;T) (T;T) | 28 |
|---|---|---|
|
| ||
rs4506565 has been reported in a large study to be associated with type-2 diabetes.
The risk allele (oriented to the dbSNP entry) is (T); the odds ratio associated with heterozygotes is 1.36 (CI 1.2-1.54), and for homozygotes, 1.88 (CI 1.56-2.27). [PMID 17554300
]
Note: this is one of two SNPs within the TCF7L2 gene that have been reported to be associated with type-2 diabetes, the other being rs7903146. They have approximately equal power to estimate risk for type-2 diabetes, and the results from one correlate 92% of the time with the other. [PMID 17554300]
[PMID 20018066] Epistatic interactions of CDKN2B-TCF7L2 for risk of type 2 diabetes and of CDKN2B-JAZF1 for triglyceride/high-density lipoprotein ratio longitudinal change: evidence from the Framingham Heart Study
| GWAS snp | |
|---|---|
| PMID | [PMID 20081858]
|
| Trait | Fasting glucose-related traits |
| Title | New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk |
| Risk Allele | T |
| P-val | 1E-8 |
| Odds Ratio | None None |
[PMID 20597906] A Validation Study of Type 2 Diabetes-related Variants of the TCF7L2, HHEX, KCNJ11, and ADIPOQ Genes in one Endogamous Ethnic Group of North India
[PMID 22402060] Functional analysis of TCF7L2 genetic variants associated with type 2 diabetes
[PMID 16936215] Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk.
[PMID 17093941] Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population.
[PMID 17934151] A variant of the transcription factor 7-like 2 (TCF7L2) gene and the risk of posttransplantation diabetes mellitus in renal allograft recipients.
[PMID 18224312] Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.
[PMID 18655717] Weak or no association of TCF7L2 variants with Type 2 diabetes risk in an Arab population.
[PMID 19053027] Loci of TCF7L2, HHEX and IDE on chromosome 10q and the susceptibility of their genetic polymorphisms to type 2 diabetes.
[PMID 19161620] An open access database of genome-wide association results.
[PMID 19252133] Interrogating type 2 diabetes genome-wide association data using a biological pathway-based approach.
[PMID 19351735] Evidence for association between polycystic ovary syndrome (PCOS) and TCF7L2 and glucose intolerance in women with PCOS and TCF7L2.
[PMID 19913122] ATRIUM: testing untyped SNPs in case-control association studies with related individuals.
[PMID 19931040] Simultaneous genotype calling and haplotype phasing improves genotype accuracy and reduces false-positive associations for genome-wide association studies.
[PMID 22583123] Association of TCF7L2 and ADIPOQ with Body Mass Index, Waist-Hip Ratio, and Systolic Blood Pressure in an Endogamous Ethnic Group of India.
[PMID 23188737] TCF7L2 gene polymorphisms and type 2 diabetes risk: a comprehensive and updated meta-analysis involving 121,174 subjects
[PMID 24128935] Impact of TCF7L2 single nucleotide polymorphisms on hydrochlorothiazide-induced diabetes
[PMID 24157263] Polymorphisms of Transcription Factor-7-Like 2 (TCF7L2) gene in Tunisian women with polycystic ovaries syndrome (PCOS)
[PMID 23107111] Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Lebanese subjects.
[PMID 23142382] Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Tunisian Arab subjects.
[PMID 27383215] Type 2 Diabetes Risk Allele Loci in the Qatari Population.
[PMID 30858716] Interaction between dietary patterns and TCF7L2 polymorphisms on type 2 diabetes mellitus among Uyghur adults in Xinjiang Province, China.
[PMID 32445548] Association between type 2 diabetes mellitus & TCF7L2 gene variants in the Emirati population: Genetics of diabetes in the United Arab Emirates.
