rs45446698
From SNPedia
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 0 | common/normal |
| (A;C) | 3 | Carrier of a CYP3A7*1C allele; possibly reduced contraceptive effectiveness and slightly increased cancer risk |
| (C;C) | 3.9 | Carrier of two CYP3A7*1C alleles; possibly reduced contraceptive effectiveness and moderately increased cancer risk |
| Reference | GRCh38.p2 38.2/146 |
| Chromosome | 7 |
| Position | 99735325 |
| Gene | CYP3A7, CYP3A7-CYP3A51P, ZSCAN25 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs45446698 |
| dbSNP (classic) | rs45446698 |
| ClinGen | rs45446698 |
| ebi | rs45446698 |
| HLI | rs45446698 |
| Exac | rs45446698 |
| Gnomad | rs45446698 |
| Varsome | rs45446698 |
| LitVar | rs45446698 |
| Map | rs45446698 |
| PheGenI | rs45446698 |
| Biobank | rs45446698 |
| 1000 genomes | rs45446698 |
| hgdp | rs45446698 |
| ensembl | rs45446698 |
| geneview | rs45446698 |
| scholar | rs45446698 |
| rs45446698 | |
| pharmgkb | rs45446698 |
| gwascentral | rs45446698 |
| openSNP | rs45446698 |
| 23andMe | rs45446698 |
| SNPshot | rs45446698 |
| SNPdbe | rs45446698 |
| MSV3d | rs45446698 |
| GWAS Ctlg | rs45446698 |
| Max Magnitude | 3.9 |
CYP3A7 is normally turned on in an embryo, then turned off at birth. However, individuals with one of more copy of the gene (CYP3A7*1C) turn on their CYP3A7 gene in adult life. C allele increased risk of breast cancer, lung cancer, and CLL.
Analyses adjusted for prognostic factors showed harboring the SNP increased risk for disease-specific mortality 74% among patients with breast cancer (HR = 1.74; 95% CI, 1.05-2.9) and 43% among patients with lung cancer (HR = 1.43; 95% CI, 1.09-1.87).
