rs4626664
From SNPedia
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 2 | >1.44x increased risk of developing restless legs syndrome |
| (A;G) | 1.5 | 1.44x increased risk of developing restless legs syndrome |
| (G;G) | 1 | Normal risk of developing restless legs syndrome |
| Reference | GRCh37 37.1/131 |
| Chromosome | 9 |
| Position | 9261737 |
| Gene | PTPRD |
| is a | snp |
| is | mentioned by |
| dbSNP | rs4626664 |
| dbSNP (classic) | rs4626664 |
| ClinGen | rs4626664 |
| ebi | rs4626664 |
| HLI | rs4626664 |
| Exac | rs4626664 |
| Gnomad | rs4626664 |
| Varsome | rs4626664 |
| LitVar | rs4626664 |
| Map | rs4626664 |
| PheGenI | rs4626664 |
| Biobank | rs4626664 |
| 1000 genomes | rs4626664 |
| hgdp | rs4626664 |
| ensembl | rs4626664 |
| geneview | rs4626664 |
| scholar | rs4626664 |
| rs4626664 | |
| pharmgkb | rs4626664 |
| gwascentral | rs4626664 |
| openSNP | rs4626664 |
| 23andMe | rs4626664 |
| SNPshot | rs4626664 |
| SNPdbe | rs4626664 |
| MSV3d | rs4626664 |
| GWAS Ctlg | rs4626664 |
| GMAF | 0.2553 |
| Max Magnitude | 2 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs4626664, a SNP in the motor neuron PTPRD gene, has been linked to restless legs syndrome based on a study of several European populations totaling ~2,500 patients. The odds ratio associated with the rs4626664(A) risk allele is 1.44 (CI: 1.31-1.59, adjusted p = 5 x 10e-10). [PMID 18660810]
Note that a nearby SNP, rs1975197, was also shown to independently confer risk for restless legs syndrome in this same study.
| GWAS | |
|---|---|
| SNP | rs4626664 |
| PubMedID | [PMID 18660810] |
| Condition | Restless legs syndrome |
| Gene | PTPRD |
| Risk Allele | A |
| pValue | 6.00E-010 |
| OR | 1.44 |
| 95% CI | 1.31-1.59 |
[PMID 21264940
] Family-based and population-based association studies validate PTPRD as a risk factor for restless legs syndrome
