rs4693075

Orientation

plus

Stabilized

plus

Make rs4693075(C;G)

Reference

GRCh38 38.1/141

Chromosome

4

Position

83271015

Gene

COQ2

is a	snp
is	mentioned by
dbSNP	rs4693075
dbSNP (classic)	rs4693075
ClinGen	rs4693075
ebi	rs4693075
HLI	rs4693075
Exac	rs4693075
Gnomad	rs4693075
Varsome	rs4693075
LitVar	rs4693075
Map	rs4693075
PheGenI	rs4693075
Biobank	rs4693075
1000 genomes	rs4693075
hgdp	rs4693075
ensembl	rs4693075
geneview	rs4693075
scholar	rs4693075
google	rs4693075
pharmgkb	rs4693075
gwascentral	rs4693075
openSNP	rs4693075
23andMe	rs4693075
SNPshot	rs4693075
SNPdbe	rs4693075
MSV3d	rs4693075
GWAS Ctlg	rs4693075

GMAF

0.3292

Max Magnitude

0

Non-coding polymorphism in intron 4 of the COQ2 gene; referred to as 'SNP2' in [PMID 17376224 ]

[PMID 17376224 ] rs4693075(G;G) 2.3x odds of myopathy when taking statins

Statin Response

Warning: ambiguous flip confusion possible

?

(C;C) (C;G) (G;G)

28

[PMID 23942138 ] SLCO1B1 Genetic Variant Associated With Statin-Induced Myopathy: A Proof of Concept Study Using the Clinical Practice Research Datalink (CPRD)

[PMID 19406828 ] Inverse correlation between HPSE gene single nucleotide polymorphisms and heparanase expression: possibility of multiple levels of heparanase regulation.

ClinVar
Risk	Rs4693075(C;C) rs4693075(T;T)
Alt	Rs4693075(C;C) rs4693075(T;T)
Reference	Rs4693075(G;G)
Significance	Drug-response
Disease	rosuvastatin response - Toxicity/ADR atorvastatin response - Toxicity/ADR hmg coa reductase inhibitors response - Toxicity/ADR
Variation	info
Gene	COQ2
CLNDBN	rosuvastatin response - Toxicity/ADR atorvastatin response - Toxicity/ADR hmg coa reductase inhibitors response - Toxicity/ADR
Reversed	0
HGVS	NC_000004.11:g.84192168G>C
CLNSRC	PharmGKB Clinical Annotation
CLNACC	RCV000211139.1, RCV000211267.1, RCV000211353.1,