rs4846049

plus

Geno	Mag	Summary
(T;T)	0	common in clinvar

Make rs4846049(G;G)

Make rs4846049(G;T)

Reference

GRCh38 38.1/141

Chromosome

1

Position

11790308

Gene

MTHFR

is a	snp
is	mentioned by
dbSNP	rs4846049
dbSNP (classic)	rs4846049
ClinGen	rs4846049
ebi	rs4846049
HLI	rs4846049
Exac	rs4846049
Gnomad	rs4846049
Varsome	rs4846049
LitVar	rs4846049
Map	rs4846049
PheGenI	rs4846049
Biobank	rs4846049
1000 genomes	rs4846049
hgdp	rs4846049
ensembl	rs4846049
geneview	rs4846049
scholar	rs4846049
google	rs4846049
pharmgkb	rs4846049
gwascentral	rs4846049
openSNP	rs4846049
23andMe	rs4846049
SNPshot	rs4846049
SNPdbe	rs4846049
MSV3d	rs4846049
GWAS Ctlg	rs4846049

GMAF

0.3104

Max Magnitude

0

?

(G;G) (G;T) (T;T)

28

[PMID 19593234 ] Association analyses suggest multiple interaction effects of the methylenetetrahydrofolate reductase polymorphisms on timing of menarche and natural menopause in white women

[PMID 22647417] The human MTHFR rs4846049 polymorphism increases coronary heart disease risk through modifying miRNA binding

[PMID 20962791] Methylenetetrahydrofolate reductase gene polymorphisms and cerebral palsy in Chinese infants.

[PMID 25882505] Women who deliver twins are more likely to smoke and have high frequencies of specific SNPs: Results from a sample of African-American women who delivered preterm, low birth weight babies

ClinVar
Risk	rs4846049(G;G)
Alt	rs4846049(G;G)
Reference	Rs4846049(T;T)
Significance	Probable-non-pathogenic
Disease	Neural tube defects
Variation	info
Gene	MTHFR
CLNDBN	Neural tube defects, folate-sensitive
Reversed	0
HGVS	NC_000001.10:g.11850365T>G
CLNSRC
CLNACC	RCV000405126.1,

[PMID 32117640 ] Single nucleotide polymorphism of MTHFR rs1801133 associated with elevated Hcy levels affects susceptibility to cerebral small vessel disease.