rs4977756
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;G) | 1.2 | 1.39x higher risk for glioma development |
| (G;G) | 1.4 | 1.93x higher risk for glioma development |
| Make rs4977756(A;A) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 9 |
| Position | 22068653 |
| Gene | CDKN2B-AS1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs4977756 |
| dbSNP (classic) | rs4977756 |
| ClinGen | rs4977756 |
| ebi | rs4977756 |
| HLI | rs4977756 |
| Exac | rs4977756 |
| Gnomad | rs4977756 |
| Varsome | rs4977756 |
| LitVar | rs4977756 |
| Map | rs4977756 |
| PheGenI | rs4977756 |
| Biobank | rs4977756 |
| 1000 genomes | rs4977756 |
| hgdp | rs4977756 |
| ensembl | rs4977756 |
| geneview | rs4977756 |
| scholar | rs4977756 |
| rs4977756 | |
| pharmgkb | rs4977756 |
| gwascentral | rs4977756 |
| openSNP | rs4977756 |
| 23andMe | rs4977756 |
| SNPshot | rs4977756 |
| SNPdbe | rs4977756 |
| MSV3d | rs4977756 |
| GWAS Ctlg | rs4977756 |
| GMAF | 0.3049 |
| Max Magnitude | 1.4 |
rs4977756 is a SNP near the CDKN2BAS gene.
A (GWA) study for open-angle glaucoma (OAG) blindness ultimately based on ~1500 cases concluded that the rather common rs4977756(A) allele was statistically associated with the condition, with a per allele odds ratio of 1.39 (CI: 1.28–1.51, p = 1.35 × 10e?14).[PMID 21532571]
[PMID 28472212] Association of Glaucoma-Susceptible Genes to Regional Circumpapillary Retinal Nerve Fiber Layer Thickness and Visual Field Defects
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
| GWAS snp | |
|---|---|
| PMID | [PMID 19578367 ]
|
| Trait | Glioma |
| Title | Genome-wide association study identifies five susceptibility loci for glioma |
| Risk Allele | G |
| P-val | 7E-15 |
| Odds Ratio | 1.24 [1.19-1.30] |
[PMID 20462933] Interaction between 5 genetic variants and allergy in glioma risk
[PMID 20847058] Genetic risk profiles identify different molecular etiologies for glioma
[PMID 20211558] Genetic advances in glioma: susceptibility genes and networks
[PMID 19578366] Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility.
[PMID 20212223] New insights into susceptibility to glioma.
[PMID 21825990] Genetic causes of glioma: new leads in the labyrinth.
| GWAS snp | |
|---|---|
| PMID | [PMID 22886559]
|
| Trait | Glioma |
| Title | Genome-wide association study of glioma and meta-analysis. |
| Risk Allele | G |
| P-val | 1E-8 |
| Odds Ratio | 1.28 [1.177-1.398] |
[PMID 23115063] Known glioma risk loci are associated with glioma with a family history of brain tumours -- a case-control gene association study
[PMID 23161787] Association between glioma susceptibility loci and tumour pathology defines specific molecular etiologies
[PMID 25165198] Mutation-based molecular glioma classification: prevalence and association with germline risk snps
[PMID 26243184] An Updated and Comprehensive Meta-Analysis of Association Between Seven Hot Loci Polymorphisms from Eight GWAS and Glioma Risk
[PMID 26014354] CCDC26, CDKN2BAS, RTEL1 and TERT Polymorphisms in pediatric brain tumor susceptibility
[PMID 26577493] Effect of CDKN2A/B rs4977756 polymorphism on glioma risk: a meta-analysis of 16 studies including 24077 participants
[PMID 26839018] Genetic risk variants in the CDKN2A/B, RTEL1 and EGFR genes are associated with somatic biomarkers in glioma.
[PMID 27617221] Two gene polymorphisms (rs4977756 and rs11515) in CDKN2A/B and glioma risk in South Indian population.
