rs498872
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | |
| (C;T) | 1.2 | 1.2x higher risk for glioma development |
| (T;T) | 1.4 | 1.4x higher risk for glioma development |
| Reference | GRCh38 38.1/141 |
| Chromosome | 11 |
| Position | 118606652 |
| Gene | PHLDB1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs498872 |
| dbSNP (classic) | rs498872 |
| ClinGen | rs498872 |
| ebi | rs498872 |
| HLI | rs498872 |
| Exac | rs498872 |
| Gnomad | rs498872 |
| Varsome | rs498872 |
| LitVar | rs498872 |
| Map | rs498872 |
| PheGenI | rs498872 |
| Biobank | rs498872 |
| 1000 genomes | rs498872 |
| hgdp | rs498872 |
| ensembl | rs498872 |
| geneview | rs498872 |
| scholar | rs498872 |
| rs498872 | |
| pharmgkb | rs498872 |
| gwascentral | rs498872 |
| openSNP | rs498872 |
| 23andMe | rs498872 |
| SNPshot | rs498872 |
| SNPdbe | rs498872 |
| MSV3d | rs498872 |
| GWAS Ctlg | rs498872 |
| GMAF | 0.2328 |
| Max Magnitude | 1.4 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
23andMe blog rs498872 A 1.18 Glioma
| GWAS snp | |
|---|---|
| PMID | [PMID 19578367 ]
|
| Trait | Glioma |
| Title | Genome-wide association study identifies five susceptibility loci for glioma |
| Risk Allele | T |
| P-val | 1E-8 |
| Odds Ratio | 1.18 [1.13-1.24] |
[PMID 20462933] Interaction between 5 genetic variants and allergy in glioma risk
[PMID 20847058] Genetic risk profiles identify different molecular etiologies for glioma
[PMID 20211558] Genetic advances in glioma: susceptibility genes and networks
[PMID 21350045] Association of sequence variants on chromosomes 20, 11, and 5 (20q13.33, 11q23.3, and 5p15.33) with glioma susceptibility in a Chinese population
| GWAS snp | |
|---|---|
| PMID | [PMID 21531791]
|
| Trait | |
| Title | Chromosome 7p11.2 (EGFR) variation influences glioma risk. |
| Risk Allele | |
| P-val | 5E-11 |
| Odds Ratio | 1.2200 [NR] |
[PMID 17846999] A chromosome 11q quantitative-trait locus influences change of blood-pressure measurements over time in Mexican Americans of the San Antonio Family Heart Study.
[PMID 20212223] New insights into susceptibility to glioma.
[PMID 21825990] Genetic causes of glioma: new leads in the labyrinth.
[PMID 23361564] Inherited variant on chromosome 11q23 increases susceptibility to IDH-mutated but not IDH-normal gliomas regardless of grade or histology
[PMID 23161787] Association between glioma susceptibility loci and tumour pathology defines specific molecular etiologies
[PMID 23733245] Genetic variants in telomerase-related genes are associated with an older age at diagnosis in glioma patients: evidence for distinct pathways of gliomagenesis.
[PMID 24935770] The PHLDB1 rs498872 (11q23.3) polymorphism and glioma risk: A meta-analysis
[PMID 25165198] Mutation-based molecular glioma classification: prevalence and association with germline risk snps
[PMID 25182002] Assessment of Glioma Risk Associated with an Inherited Variant at Chromosome 11q23
[PMID 26243184] An Updated and Comprehensive Meta-Analysis of Association Between Seven Hot Loci Polymorphisms from Eight GWAS and Glioma Risk
[PMID 26610392] Functional analysis of the 11q23.3 glioma susceptibility locus implicates PHLDB1 and DDX6 in glioma susceptibility.
