rs5015480

Orientation

plus

Stabilized

plus

Make rs5015480(C;C)

Make rs5015480(C;T)

Make rs5015480(T;T)

Reference

GRCh38 38.1/142

Chromosome

10

Position

92705802

is a	snp
is	mentioned by
dbSNP	rs5015480
dbSNP (classic)	rs5015480
ClinGen	rs5015480
ebi	rs5015480
HLI	rs5015480
Exac	rs5015480
Gnomad	rs5015480
Varsome	rs5015480
LitVar	rs5015480
Map	rs5015480
PheGenI	rs5015480
Biobank	rs5015480
1000 genomes	rs5015480
hgdp	rs5015480
ensembl	rs5015480
geneview	rs5015480
scholar	rs5015480
google	rs5015480
pharmgkb	rs5015480
gwascentral	rs5015480
openSNP	rs5015480
23andMe	rs5015480
SNPshot	rs5015480
SNPdbe	rs5015480
MSV3d	rs5015480
GWAS Ctlg	rs5015480

GMAF

0.4605

Max Magnitude

0

?	(C;C) (C;T) (T;T)	28

[PMID 17928989] associated with type-2 diabetes, but then called into question by 10.1371/journal.pbio.1000294 along with rs9300039 rs4402960 rs7754840 rs17044137 rs11037909 rs1081161 rs1111875 rs7923837 rs12885713 rs1219648 rs2981582

GWAS
SNP	rs5015480
PubMedID	[PMID 17463249]
Condition	Type 2 diabetes
Gene	HHEX
Risk Allele	C
pValue	6.00E-010
OR	1.13
95% CI	1.08-1.17

GWAS snp
PMID	[PMID 18372903]
Trait	Type 2 diabetes
Title	Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
Risk Allele	C
P-val	7.0000000000000005E-8
Odds Ratio	1.17 [1.11-1.24]

[PMID 19622614] HHEX-IDE polymorphism is associated with low birth weight in offspring with a family history of type 1 diabetes

[PMID 20503258] Candidate gene association study conditioning on individual ancestry in patients with type 2 diabetes and metabolic syndrome from Mexico City

GWAS snp
PMID	[PMID 20581827]
Trait	Type 2 diabetes
Title	Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
Risk Allele	C
P-val	1E-15
Odds Ratio	1.18 [1.13-1.23]

GWAS snp
PMID	[PMID 20862305]
Trait
Title	Identification of new genetic risk variants for type 2 diabetes
Risk Allele	C
P-val	0.000009
Odds Ratio	1.17 [1.11-1.24]

[PMID 22558147] Lack of Association of Type 2 Diabetes Susceptibility Genotypes and Body Weight on the Development of Islet Autoimmunity and Type 1 Diabetes

[PMID 17786212] Heterogeneity in meta-analyses of genome-wide association investigations.

[PMID 18426861] Association analysis of type 2 diabetes Loci in type 1 diabetes.

[PMID 18443202] Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies.

[PMID 18469204] Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians.

[PMID 18633108] Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population.

[PMID 19002430] Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population.

[PMID 19056611] Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.

[PMID 19207020] Meta-analysis in genome-wide association studies.

[PMID 19323962] Genome-wide association studies in type 2 diabetes.

[PMID 19526209] Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?

[PMID 19602701] Underlying genetic models of inheritance in established type 2 diabetes associations.

[PMID 19741467] Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea.

[PMID 19931040] Simultaneous genotype calling and haplotype phasing improves genotype accuracy and reduces false-positive associations for genome-wide association studies.

[PMID 20017978] Influence of control selection in genome-wide association studies: the example of diabetes in the Framingham Heart Study.

[PMID 20018041] The effect of multiple genetic variants in predicting the risk of type 2 diabetes.

[PMID 20126254] Rare variants create synthetic genome-wide associations.

[PMID 20144327] A genomics study of type 2 diabetes mellitus in U.S. Air Force personnel.

[PMID 20509872] Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population.

[PMID 20532014] The epidemiology of diabetes in Korea: from the economics to genetics.

[PMID 20550665] Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population.

[PMID 21368910] Heterogeneity of genetic associations of CDKAL1 and HHEX with susceptibility of type 2 diabetes mellitus by gender.

[PMID 22377712] Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography.

GWAS snp
PMID	[PMID 22693455]
Trait
Title	Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.
Risk Allele	C
P-val	2E-9
Odds Ratio	1.1800 None

[PMID 24112421] CDKAL1 and HHEX are associated with type-2 diabetes-related traits among Yup'ik people

[PMID 24371822] IRS1, TCF7L2, ADRB1, PPARG, and HHEX Polymorphisms Associated with Atherogenic Risk in Mexican Population

[PMID 23298195] Association study of genetic variants of 17 diabetes-related genes/loci and cardiovascular risk and diabetic nephropathy in the Chinese She population.

[PMID 23462794] Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets.

[PMID 29720110] Effect of smoking on the association of HHEX (rs5015480) with diabetes among Korean women and heavy smoking men.