rs505922
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 2.1 | blood type is not O, increased risk for some diseases. |
| (C;T) | 1.2x risk of pancreatic cancer | |
| (T;T) | 2 | blood type O |
| Reference | GRCh38 38.1/141 |
| Chromosome | 9 |
| Position | 133273813 |
| Gene | ABO |
| is a | snp |
| is | mentioned by |
| dbSNP | rs505922 |
| dbSNP (classic) | rs505922 |
| ClinGen | rs505922 |
| ebi | rs505922 |
| HLI | rs505922 |
| Exac | rs505922 |
| Gnomad | rs505922 |
| Varsome | rs505922 |
| LitVar | rs505922 |
| Map | rs505922 |
| PheGenI | rs505922 |
| Biobank | rs505922 |
| 1000 genomes | rs505922 |
| hgdp | rs505922 |
| ensembl | rs505922 |
| geneview | rs505922 |
| scholar | rs505922 |
| rs505922 | |
| pharmgkb | rs505922 |
| gwascentral | rs505922 |
| openSNP | rs505922 |
| 23andMe | rs505922 |
| SNPshot | rs505922 |
| SNPdbe | rs505922 |
| MSV3d | rs505922 |
| GWAS Ctlg | rs505922 |
| GMAF | 0.3484 |
| Max Magnitude | 2.1 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
23andMe blog each copy rs505922(C) is associated with 1.2x risk of pancreatic cancer
influences ABO blood group
[PMID 25656610] Association between ABO gene polymorphism (rs505922) and cancer risk: a meta-analysis
[PMID 23816557
] Re-evaluation of ABO gene polymorphisms detected in a genome-wide association study and risk of pancreatic ductal adenocarcinoma in a Chinese population.
[PMID 23704932] Impact of PSCA Variation on Gastric Ulcer Susceptibility
[PMID 23381943] Ischemic stroke is associated with the ABO locus: The EuroCLOT study
[PMID 22665904] A Replication Study and Genome-wide Scan of Single Nucleotide Polymorphisms Associated with Pancreatic Cancer Risk and Overall Survival
[PMID 22642827] Relationships between the ABO blood group SNP rs505922 and breast cancer phenotypes: a genotypephenotype correlation study
[PMID 22387998] A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population
[PMID 22147973] Pancreatic cancer risk variant ABO rs505922 in patients with cholangiocarcinoma
[PMID 21792085] ABO blood group and chronic pancreatitis risk in the NAPS2 cohort.
[PMID 21306478] ABO blood group alleles and the risk of pancreatic cancer in a Japanese population.
[PMID 20686608] Genome-wide association study of pancreatic cancer in Japanese population.
[PMID 20101243] A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33.
[PMID 19729612] Genome-wide association identifies the ABO blood group as a major locus associated with serum levels of soluble E-selectin.
[PMID 19648918] Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer
[PMID 19474294] Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.
[PMID 18604267] Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 women.
| GWAS snp | |
|---|---|
| PMID | [PMID 19278955] |
| Trait | Venous thromboembolism |
| Title | Common susceptibility allele are unlikely to contribute as strongly as the FV and ABO loci to VTE risk: results from a GWAS approach |
| Risk Allele | C |
| P-val | 4E-15 |
| Odds Ratio | 1.81 [1.56-2.11] |
| GWAS snp | |
|---|---|
| PMID | [PMID 18464913]
|
| Trait | Protein quantitative trait loci |
| Title | A Genome-Wide Association Study Identifies Protein Quantitative Trait Loci (pQTLs) |
| Risk Allele | |
| P-val | 7.0000000000000003E-40 |
| Odds Ratio | NR NR |
| GWAS snp | |
|---|---|
| PMID | [PMID 21980494]
|
| Trait | |
| Title | Genetics of venous thrombosis: insights from a new genome wide association study. |
| Risk Allele | C |
| P-val | 1E-34 |
| Odds Ratio | 1.9200 [NR] |
| GWAS snp | |
|---|---|
| PMID | [PMID 21841780] |
| Trait | |
| Title | A genome-wide association study identifies two new risk loci for Graves' disease. |
| Risk Allele | T |
| P-val | 0.000008 |
| Odds Ratio | 1.1300 [1.07-1.20] |
| GWAS snp | |
|---|---|
| PMID | [PMID 23612905] |
| Trait | Graves' disease |
| Title | Robust evidence for five new Graves' disease risk loci from a staged genome-wide association analysis. |
| Risk Allele | |
| P-val | 2E-10 |
| Odds Ratio | 1.14 [1.1-1.19] |
[PMID 26924317] Fine-Mapping of ABO Gene Identifies Two Novel SNPs Associated with Large Artery Atherosclerotic Stroke in a Chinese Han Population.
[PMID 33053422] Association between polymorphisms in ABO gene and stroke patients with small artery occlusion in southern Chinese Han population.
