rs515726123

Orientation

plus

Stabilized

plus

Geno	Mag	Summary
(-;-)	7	Fanconi anemia, complementation group N
(-;CT)	3	2-4 fold higher risk for breast cancer, depending on family history
(-;TC)	5	PALB2-related cancer risk
(CT;CT)	0	common/normal
(TC;TC)	0	common in clinvar

Reference

GRCh38 38.1/141

Chromosome

16

Position

23636037

Gene

PALB2

is a	snp
is	mentioned by
dbSNP	rs515726123
dbSNP (classic)	rs515726123
ClinGen	rs515726123
ebi	rs515726123
HLI	rs515726123
Exac	rs515726123
Gnomad	rs515726123
Varsome	rs515726123
LitVar	rs515726123
Map	rs515726123
PheGenI	rs515726123
Biobank	rs515726123
1000 genomes	rs515726123
hgdp	rs515726123
ensembl	rs515726123
geneview	rs515726123
scholar	rs515726123
google	rs515726123
pharmgkb	rs515726123
gwascentral	rs515726123
openSNP	rs515726123
23andMe	rs515726123
SNPshot	rs515726123
SNPdbe	rs515726123
MSV3d	rs515726123
GWAS Ctlg	rs515726123

Merged from

Rs515726124

Max Magnitude

7

[PMID 25099575] Breast-Cancer Risk in Families with Mutations in PALB2

see also ClinVar (where clinical significance = pathogenic)

ClinVar
Risk	Rs515726123(-;-) Rs515726123(TC;TC)
Alt	Rs515726123(-;-) Rs515726123(TC;TC)
Reference	Rs515726123(CT;CT)
Significance	Pathogenic
Disease	Familial cancer of breast Pancreatic cancer 3 Hereditary cancer-predisposing syndrome not provided PALB2-Related Disorders
Variation	info
Gene	PALB2
CLNDBN	Familial cancer of breast Pancreatic cancer 3 Hereditary cancer-predisposing syndrome not provided PALB2-Related Disorders
Reversed	0
HGVS	NC_000016.9:g.23647357_23647358delTC
CLNSRC	PALB2 database
CLNACC	RCV000114645.6, RCV000114646.1, RCV000130658.7, RCV000212776.2, RCV000363454.1,