rs5558

plus

Geno	Mag	Summary
(A;A)	0
(G;G)		None
(T;G)		None
(T;T)	0	normal

Make rs5558(G;T)

Reference

GRCh38 38.1/141

Chromosome

16

Position

55699647

Gene

SLC6A2

is a	snp
is	mentioned by
dbSNP	rs5558
dbSNP (classic)	rs5558
ClinGen	rs5558
ebi	rs5558
HLI	rs5558
Exac	rs5558
Gnomad	rs5558
Varsome	rs5558
LitVar	rs5558
Map	rs5558
PheGenI	rs5558
Biobank	rs5558
1000 genomes	rs5558
hgdp	rs5558
ensembl	rs5558
geneview	rs5558
scholar	rs5558
google	rs5558
pharmgkb	rs5558
gwascentral	rs5558
openSNP	rs5558
23andMe	rs5558
SNPshot	rs5558
SNPdbe	rs5558
MSV3d	rs5558
GWAS Ctlg	rs5558

Max Magnitude

0

?

(G;G) (G;T) (T;T)

28

rs5558 (F528C) is a non-synonymous SNP in SLC6A2 (norepinephrine transporter), with a T encoding for Phenylalanine and C encoding the rare Cysteine variant.

[PMID 19105200] assoc. w/ major depression

[PMID 15894713] Cysteine variant exhibited increased norepinephrine transport, insensitivity to protein kinase C induced down-regulation, and a decrease in desipramine (tricyclic antidepressant) potency

[PMID 21172166 ] Pharmacogenetics of antidepressant response.