rs55886062

plus

Geno	Mag	Summary
(A;A)	0	common/normal
(A;C)	2	carrier of a null DPYD allele
(C;C)	3.5	5-fluorouracil toxicity

Reference

GRCh38 38.1/142

Chromosome

1

Position

97515787

Gene

DPYD

is a	snp
is	mentioned by
dbSNP	rs55886062
dbSNP (classic)	rs55886062
ClinGen	rs55886062
ebi	rs55886062
HLI	rs55886062
Exac	rs55886062
Gnomad	rs55886062
Varsome	rs55886062
LitVar	rs55886062
Map	rs55886062
PheGenI	rs55886062
Biobank	rs55886062
1000 genomes	rs55886062
hgdp	rs55886062
ensembl	rs55886062
geneview	rs55886062
scholar	rs55886062
google	rs55886062
pharmgkb	rs55886062
gwascentral	rs55886062
openSNP	rs55886062
23andMe	rs55886062
SNPshot	rs55886062
SNPdbe	rs55886062
MSV3d	rs55886062
GWAS Ctlg	rs55886062

Max Magnitude

3.5

rs55886062, also known as c.1679 T>G, encodes the DPYD*13 allele of the DPYD gene on chromosome 1.

Note that the terms used in the literature for this gene can be confusing, since the gene is in reverse orientation to the chromosome strand on the reference genome.

ClinVar
Risk	Rs55886062(C;C) rs55886062(T;T)
Alt	Rs55886062(C;C) rs55886062(T;T)
Reference	Rs55886062(A;A)
Significance	Drug-response
Disease	not provided fluorouracil response - Toxicity/ADR Pyrimidine analogues response - Toxicity/ADR capecitabine response - Toxicity/ADR tegafur response - Toxicity/ADR Dihydropyrimidine dehydrogenase deficiency
Variation	info
Gene	DPYD
CLNDBN	not provided fluorouracil response - Toxicity/ADR Pyrimidine analogues response - Toxicity/ADR capecitabine response - Toxicity/ADR tegafur response - Toxicity/ADR Dihydropyrimidine dehydrogenase deficiency
Reversed	0
HGVS	NC_000001.10:g.97981343A>C
CLNSRC	PharmGKB Clinical Annotation
CLNACC	RCV000086474.3, RCV000211143.1, RCV000211265.1, RCV000211360.1, RCV000211391.1, RCV000410952.1,