rs560887
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 2 | Avg. fasting Plasma Glucose 5.06 mmol/L (91 mg/dl). |
| (A;G) | 2 | Avg. fasting Plasma Glucose 5.12 mmol/L (92 mg/dl). |
| (G;G) | 2.1 | Avg. fasting Plasma Glucose 5.18 mmol/L (93 mg/dl). |
| Reference | GRCh37 37.1/131 |
| Chromosome | 2 |
| Position | 168906638 |
| Gene | G6PC2 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs560887 |
| dbSNP (classic) | rs560887 |
| ClinGen | rs560887 |
| ebi | rs560887 |
| HLI | rs560887 |
| Exac | rs560887 |
| Gnomad | rs560887 |
| Varsome | rs560887 |
| LitVar | rs560887 |
| Map | rs560887 |
| PheGenI | rs560887 |
| Biobank | rs560887 |
| 1000 genomes | rs560887 |
| hgdp | rs560887 |
| ensembl | rs560887 |
| geneview | rs560887 |
| scholar | rs560887 |
| rs560887 | |
| pharmgkb | rs560887 |
| gwascentral | rs560887 |
| openSNP | rs560887 |
| 23andMe | rs560887 |
| SNPshot | rs560887 |
| SNPdbe | rs560887 |
| MSV3d | rs560887 |
| GWAS Ctlg | rs560887 |
| GMAF | 0.1515 |
| Max Magnitude | 2.1 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
[PMID 18451265] rs560887, p = 4 x 10(-7))
- 654 normoglycemic subjects, replicated in 9,353 subjects
- fasting plasma glucose (FPG) (beta = -0.06 mmol/l per A-allele, combined p = 4 x 10(-23)) and with pancreatic beta-cell function (Homa-B model, combined p = 3 x 10(-13)) in three populations; however it was not associated with type 2 diabetes risk.
| GWAS | |
|---|---|
| SNP | rs560887 |
| PubMedID | [PMID 18451265] |
| Condition | Fasting plasma glucose |
| Gene | G6PC2 |
| Risk Allele | A |
| pValue | 4.00E-023 |
| OR | 0.06 |
| 95% CI | 0.05-0.08) mmol/l decreas |
| GWAS snp | |
|---|---|
| PMID | [PMID 19060910 ]
|
| Trait | Other metabolic traits |
| Title | Genome-wide association analysis of metabolic traits in a birth cohort from a founder population |
| Risk Allele | A |
| P-val | 6E-10 |
| Odds Ratio | 0.06 [0.04-0.07] mmol/l decrease |
| GWAS snp | |
|---|---|
| PMID | [PMID 19060907]
|
| Trait | Fasting plasma glucose |
| Title | Variants in MTNR1B influence fasting glucose levels |
| Risk Allele | C |
| P-val | 1E-57 |
| Odds Ratio | 0.06 [0.05-0.07] mmol/l increase |
[PMID 19651812] Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type-2 diabetes amongst Indian Asians and European whites
[PMID 19741166] Common Genetic Determinants of Glucose Homeostasis in Healthy Children: The European Youth Heart Study (EYHS)
[PMID 20029179] Association of a Common G6PC2 Variant with Fasting Plasma Glucose Levels in Non-Diabetic Individuals
| GWAS snp | |
|---|---|
| PMID | [PMID 20081858]
|
| Trait | Fasting glucose-related traits |
| Title | New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk |
| Risk Allele | C |
| P-val | 2E-66 |
| Odds Ratio | None None |
[PMID 20826583] The Impact of Genetic Variation in the G6PC2 Gene on Insulin Secretion Depends on Glycemia
[PMID 20839289] Impact of repeated measures and sample selection on genome-wide association studies of fasting glucose
[PMID 21036910] Association of a fasting glucose genetic risk score with subclinical atherosclerosis: The Atherosclerosis Risk in Communities (ARIC) Study
| GWAS snp | |
|---|---|
| PMID | [PMID 22508271]
|
| Trait | |
| Title | Fasting glucose GWAS candidate region analysis across ethnic groups in the Multiethnic Study of Atherosclerosis (MESA). |
| Risk Allele | T |
| P-val | 0.000002 |
| Odds Ratio | 1.2900 None |
| GWAS snp | |
|---|---|
| PMID | [PMID 22399527]
|
| Trait | |
| Title | Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. |
| Risk Allele | G |
| P-val | 5E-26 |
| Odds Ratio | 0.1500 None |
| GWAS snp | |
|---|---|
| PMID | [PMID 22286219]
|
| Trait | |
| Title | Genome-wide association study identifies multiple loci influencing human serum metabolite levels. |
| Risk Allele | |
| P-val | 2E-17 |
| Odds Ratio | 0.1500 None |
[PMID 18521185] Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels.
[PMID 18984742] A single-nucleotide polymorphism in a methylatable Foxa2 binding site of the G6PC2 promoter is associated with insulin secretion in vivo and increased promoter activity in vitro.
[PMID 19096518] Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.
[PMID 19533084] Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk.
[PMID 19669124] A variant in the G6PC2/ABCB11 locus is associated with increased fasting plasma glucose, increased basal hepatic glucose production and increased insulin release after oral and intravenous glucose loads.
[PMID 19741163] Additive effects of genetic variation in GCK and G6PC2 on insulin secretion and fasting glucose.
[PMID 19937311] Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations.
[PMID 20043853] Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus.
[PMID 20622168] Genetic and functional assessment of the role of the rs13431652-A and rs573225-A alleles in the G6PC2 promoter that are strongly associated with elevated fasting glucose levels.
[PMID 20628598] Common polymorphisms in MTNR1B, G6PC2 and GCK are associated with increased fasting plasma glucose and impaired beta-cell function in Chinese subjects.
[PMID 20870969] Genetic predisposition to long-term nondiabetic deteriorations in glucose homeostasis: Ten-year follow-up of the GLACIER study. (ageing)
| GWAS snp | |
|---|---|
| PMID | [PMID 22581228]
|
| Trait | |
| Title | A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. |
| Risk Allele | |
| P-val | 2E-113 |
| Odds Ratio | None None |
[PMID 23508304] Multiple functional polymorphisms in the G6PC2 gene contribute to the association with higher fasting plasma glucose levels
| GWAS snp | |
|---|---|
| PMID | [PMID 22916037]
|
| Trait | Metabolite levels |
| Title | Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis. |
| Risk Allele | |
| P-val | 4E-15 |
| Odds Ratio | NR NR |
[PMID 23840762] Large Scale Meta-Analyses of Fasting Plasma Glucose Raising Variants in GCK, GCKR, MTNR1B and G6PC2 and Their Impacts on Type 2 Diabetes Mellitus Risk
[PMID 22438186] A SNP in G6PC2 predicts insulin secretion in type 1 diabetes
| GWAS snp | |
|---|---|
| PMID | [PMID 23903356]
|
| Trait | Glycemic traits (pregnancy) |
| Title | Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies. |
| Risk Allele | T |
| P-val | 2E-16 |
| Odds Ratio | .01 [NR] unit decrease |
[PMID 22486180] HbA1c-based diabetes diagnosis among patients with glucokinase mutation (GCK-MODY) is affected by a genetic variant of glucose-6-phosphatase (G6PC2).
[PMID 22698489] Nonfasting glucose, ischemic heart disease, and myocardial infarction: a Mendelian randomization study.
| GWAS snp | |
|---|---|
| PMID | [PMID 24405752]
|
| Trait | Glycated hemoglobin levels |
| Title | Genome-wide association study identifies common loci influencing circulating glycated hemoglobin (HbA1c) levels in non-diabetic subjects: the Long Life Family Study (LLFS). |
| Risk Allele | T |
| P-val | 1E-17 |
| Odds Ratio | .03 [0.024-0.040] unit decrease |
