rs5751876

plus

Geno	Mag	Summary
(C;C)	0	None
(C;T)	0	None
(T;T)	2.1	significantly higher anxiety levels after moderate caffeine consumption

Reference

GRCh38 38.1/141

Chromosome

22

Position

24441333

Gene	ADORA2A, ADORA2A-AS1, SPECC1L-ADORA2A

is a	snp
is	mentioned by
dbSNP	rs5751876
dbSNP (classic)	rs5751876
ClinGen	rs5751876
ebi	rs5751876
HLI	rs5751876
Exac	rs5751876
Gnomad	rs5751876
Varsome	rs5751876
LitVar	rs5751876
Map	rs5751876
PheGenI	rs5751876
Biobank	rs5751876
1000 genomes	rs5751876
hgdp	rs5751876
ensembl	rs5751876
geneview	rs5751876
scholar	rs5751876
google	rs5751876
pharmgkb	rs5751876
gwascentral	rs5751876
openSNP	rs5751876
23andMe	rs5751876
SNPshot	rs5751876
SNPdbe	rs5751876
MSV3d	rs5751876
GWAS Ctlg	rs5751876

GMAF

0.4807

Max Magnitude

2.1

Variation at this SNP, rs5751876, also referred to as 1976C>T or 1976T>C, appears to influence how an individual responds to moderate levels (150mg) of caffeine.

T/T carriers displaying significantly increased subjective levels of anxiety after consumption. [PMID 12825092] [PMID 18305461 ]

However a PharmGKB variant annotation suggests it is (C;C) genotypes who are more sensitive to caffeine.

rs5751876 is not associated with how much coffee one drinks, though, nor with risk for Parkinson's disease, based on a study of 1,200 subjects.[PMID 18759349 ]

[PMID 19902562] Purine biosynthetic pathway genes and methotrexate response in rheumatoid arthritis patients among north Indians

[PMID 20334879] Adenosine A(2A) receptor gene: Evidence for association of risk variants with panic disorder and anxious personality "rs2298383 shows functional potential based on in silico analyses and might therefore represent the true underlying causal variant"

[PMID 21658325] Adenosine A2A receptor polymorphisms in Korean patients with systemic sclerosis

[PMID 22012471 ] ADORA2A Gene Variation, Caffeine, and Emotional Processing: A Multi-level Interaction on Startle Reflex

[PMID 22745815 ] Affect-Modulated Startle: Interactive Influence of Catechol-O-Methyltransferase Val158Met Genotype and Childhood Trauma

[PMID 19565319] Adenosine A(2A) receptor gene (ADORA2A) variants may increase autistic symptoms and anxiety in autism spectrum disorder.

[PMID 19591938] A genetic variation in the ADORA2A gene modifies age at onset in Huntington's disease.

[PMID 20386734 ] Further evidence supporting a role for gs signal transduction in severe malaria pathogenesis.

[PMID 20396431 ] Genotyping sleep disorders patients.

[PMID 20520601 ] Association of the anxiogenic and alerting effects of caffeine with ADORA2A and ADORA1 polymorphisms and habitual level of caffeine consumption.

[PMID 22336631] Caffeine increases tear volume depending on polymorphisms within the adenosine A2a receptor gene and cytochrome P450 1A2.

[PMID 23535492 ] ADORA2A polymorphism predisposes children to encephalopathy with febrile status epilepticus

[PMID 23018769 ] A survey of putative anxiety-associated genes in panic disorder patients with and without bladder symptoms

[PMID 22940476] Effects of ADORA2A gene variation and caffeine on prepulse inhibition: a multi-level risk model of anxiety.

[PMID 23332182] A study of the possible association between adenosine A2A receptor gene polymorphisms and attention-deficit hyperactivity disorder traits.

[PMID 24943643 ] Association of Adenosine Receptor Gene Polymorphisms and in vivo Adenosine A1 Receptor Binding in the Human Brain

[PMID 25629231 ] The Association of ADORA2A and ADORA2B Polymorphisms with the Risk and Severity of Chronic Heart Failure: A Case-Control Study of a Northern Chinese Population

[PMID 26066465] Categorical complexities of Plasmodium falciparum malaria in individuals is associated with genetic variations in ADORA2A and GRK5 genes

[PMID 31817803 ] The Impact of Genetic Variations in ADORA2A in the Association between Caffeine Consumption and Sleep.