rs6060369 is a SNP associated with a (slight) increase in height, in that individuals tend to be 0.44cm taller for each rs6060369(C) allele they carry. This finding was statistically significant (p=9.7x10e-7), and ultimately tested in over 28,000 individuals.[PMID 18193045
]
A haplotype of rs6060369 and rs143383, a neighboring SNP in the GDF5 gene, can be defined, which also links height to osteoarthritis since rs143383 has previously been linked to osteoarthritis.[PMID 18193045]
Medpage article
| GWAS
|
| SNP
|
rs6060369
|
| PubMedID
|
[PMID 18193045]
|
| Condition
|
Height
|
| Gene
|
BFZB
|
| Risk Allele
|
C
|
| pValue
|
2.00E-016
|
| OR
|
0.44
|
| 95% CI
|
NR) cm talle
|
| GWAS snp
|
| PMID
|
[PMID 18391950]
|
| Trait
|
Height
|
| Title
|
Identification of ten loci associated with height highlights new biological pathways in human growth
|
| Risk Allele
|
C
|
| P-val
|
9.9999999999999998E-17
|
| Odds Ratio
|
0.44 [0.34-0.72] cm taller
|
| OMIM | 612228 |
| Desc | STATURE QUANTITATIVE TRAIT LOCUS 14; STQTL14 |
| Variant | |
| Related | also |
[PMID 19030899] Genome-wide association scan for stature in Chinese: evidence for ethnic specific loci.
[PMID 19197348] Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
[PMID 20017971] Assessing the impact of global versus local ancestry in association studies.
]
