rs6195
| Merged into | rs56149945 |
| Orientation | minus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (T;T) | 0 |
| Make rs6195(A;A) |
| Make rs6195(A;G) |
| Make rs6195(G;G) |
| Reference | GRCh38 38.1/142 |
| Chromosome | 5 |
| Position | 143399752 |
| Gene | NR3C1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs6195 |
| dbSNP (classic) | rs6195 |
| ClinGen | rs6195 |
| ebi | rs6195 |
| HLI | rs6195 |
| Exac | rs6195 |
| Gnomad | rs6195 |
| Varsome | rs6195 |
| LitVar | rs6195 |
| Map | rs6195 |
| PheGenI | rs6195 |
| Biobank | rs6195 |
| 1000 genomes | rs6195 |
| hgdp | rs6195 |
| ensembl | rs6195 |
| geneview | rs6195 |
| scholar | rs6195 |
| rs6195 | |
| pharmgkb | rs6195 |
| gwascentral | rs6195 |
| openSNP | rs6195 |
| 23andMe | rs6195 |
| SNPshot | rs6195 |
| SNPdbe | rs6195 |
| MSV3d | rs6195 |
| GWAS Ctlg | rs6195 |
| Status | Merged into rs56149945 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs6195 (Asn363Ser/N363S) is a SNP within the NR3C1 (Nuclear receptor subfamily 3, group C, member 1 [glucocorticoid receptor]) gene. The common A allele encodes for Asparagine and the less common G allele encodes for Serine.
Abstract linked to increased glucocorticoid sensitivity, coronary artery disease, and increased body mass index.
[PMID 20472303] Associations between common arginine vasopressin 1b receptor and glucocorticoid receptor gene variants and HPA axis responses to psychosocial stress in a child psychiatric population
[PMID 20547006] FKBP5 and resistant attachment predict cortisol reactivity in infants: Gene-environment interaction
[PMID 22507373] Glucocorticoid receptor gene polymorphisms are associated with reduced first-phase glucose-stimulated insulin secretion and disposition index in women, but not in men
[PMID 17535992
] Molecular evidence for a link between the N363S glucocorticoid receptor polymorphism and altered gene expression.
[PMID 18854398] Glucocorticoid receptor gene variant in the 3' untranslated region is associated with multiple measures of blood pressure.
[PMID 18952539] No association of glucocorticoid receptor polymorphisms with asthma and response to glucocorticoids.
[PMID 19673019] IL-10 and TNF-alpha promoter haplotypes are associated with childhood Crohn's disease location.
[PMID 20015871] Pharmacogenetic risk factors for altered bone mineral density and body composition in pediatric acute lymphoblastic leukemia.
[PMID 20199670] Glucocorticoid receptor gene polymorphisms do not affect growth in fetal and early postnatal life. The Generation R Study.
[PMID 20592916] Pharmacogenomic approaches to asthma treatment.
[PMID 21448414] Molecular mechanism of glucocorticoid resistance in inflammatory bowel disease.
[PMID 21803757] Genetic polymorphisms of the glucocorticoid receptor may affect the phenotype of women with anovulatory polycystic ovary syndrome.
[PMID 21876507] Glucocorticoid receptor polymorphism is associated with lithium response in bipolar patients.
[PMID 22781842] Variation in the glucocorticoid receptor gene at rs41423247 moderates the effect of prenatal maternal psychological symptoms on child cortisol reactivity and behavior
[PMID 25709928] Clinical relevance of the glucocorticoid receptor gene polymorphisms in glucocorticoid-induced ocular hypertension and primary open angle glaucoma
[PMID 25724472] Polymorphisms in the glucocorticoid receptor gene and in the glucocorticoid-induced transcript 1 gene are associated with disease activity and response to glucocorticoid bridging therapy in rheumatoid arthritis
[PMID 25843653] GLCCI1 and Glucocorticoid Receptor Genetic Diversity and Response to Glucocorticoid-Based Treatment of Graft-versus-Host Disease.
[PMID 33562675] The Glucocorticoid Receptor Gene (NR3C1) 9β SNP Is Associated with Posttraumatic Stress Disorder.
