rs6564851
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (G;G) | higher beta-carotene levels | |
| (G;T) | higher beta-carotene levels | |
| (T;T) | normal |
| Reference | GRCh38 38.1/141 |
| Chromosome | 16 |
| Position | 81230992 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs6564851 |
| dbSNP (classic) | rs6564851 |
| ClinGen | rs6564851 |
| ebi | rs6564851 |
| HLI | rs6564851 |
| Exac | rs6564851 |
| Gnomad | rs6564851 |
| Varsome | rs6564851 |
| LitVar | rs6564851 |
| Map | rs6564851 |
| PheGenI | rs6564851 |
| Biobank | rs6564851 |
| 1000 genomes | rs6564851 |
| hgdp | rs6564851 |
| ensembl | rs6564851 |
| geneview | rs6564851 |
| scholar | rs6564851 |
| rs6564851 | |
| pharmgkb | rs6564851 |
| gwascentral | rs6564851 |
| openSNP | rs6564851 |
| 23andMe | rs6564851 |
| SNPshot | rs6564851 |
| SNPdbe | rs6564851 |
| MSV3d | rs6564851 |
| GWAS Ctlg | rs6564851 |
| GMAF | 0.4316 |
| Max Magnitude | 0 |
| ? | (G;G) (G;T) (T;T) | 28 |
|---|---|---|
|
| ||
[PMID 19185284
] rs6564851(G) associated with higher beta-carotene (p = 1.6 x 10(-24)) and alpha-carotene (p = 0.0001) levels and lower lycopene (0.003), zeaxanthin (p = 1.3 x 10(-5)), and lutein (p = 7.3 x 10(-15)) levels, with effect sizes ranging from 0.10-0.28 SDs per allele.
Note that low plasma levels of carotenoids and tocopherols are associated with increased risk of chronic disease and disability, yet dietary intake of these lipid-soluble antioxidant vitamins is only poorly correlated with plasma levels, leading to the hypothesis that it isn't what you eat, it's your SNPs that regulate your carotenoid levels.[PMID 19185284]
This is one of the SNPs reported by NutraHacker.
[PMID 19662379] Circulating beta-carotene levels and type 2 diabetes-cause or effect?
[PMID 20616999] Usefulness of Mendelian randomization in observational epidemiology.
[PMID 22113863] Single nucleotide polymorphisms upstream from the beta-carotene 15,15'-monoxygenase gene influence provitamin A conversion efficiency in female volunteers.
[PMID 23468552] Genetic variants influencing biomarkers of nutrition are not associated with cognitive capability in middle-aged and older adults.
