A study of 219 female melanoma patients and an equal number of controls concluded that 4 linked SNPs within the IL6R gene were associated with increased melanoma risk, but only when heterozygous. [Note that there may have been too few minor allele homozygotes to study, though.] The odds ratio associated with the minor allele of this SNP, rs6684439, was 1.74 (CI: 1.07-2.81). The 4 linked SNPs from identified in this study are: rs6684439, rs4845618, rs4845622, and rs8192284.[PMID 18781131
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[PMID 18852330] Interleukin-6 receptor gene, plasma C-reactive protein, and diabetes risk in women.
[PMID 19124510] Insulin-like growth factor-1- and interleukin-6-related gene variation and risk of multiple myeloma.
[PMID 20031577] Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.
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