rs6782400
From SNPedia
| Orientation | plus |
| Stabilized | plus |
| Make rs6782400(A;A) |
| Make rs6782400(A;C) |
| Make rs6782400(C;C) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 3 |
| Position | 142576526 |
| Gene | ATR |
| is a | snp |
| is | mentioned by |
| dbSNP | rs6782400 |
| dbSNP (classic) | rs6782400 |
| ClinGen | rs6782400 |
| ebi | rs6782400 |
| HLI | rs6782400 |
| Exac | rs6782400 |
| Gnomad | rs6782400 |
| Varsome | rs6782400 |
| LitVar | rs6782400 |
| Map | rs6782400 |
| PheGenI | rs6782400 |
| Biobank | rs6782400 |
| 1000 genomes | rs6782400 |
| hgdp | rs6782400 |
| ensembl | rs6782400 |
| geneview | rs6782400 |
| scholar | rs6782400 |
| rs6782400 | |
| pharmgkb | rs6782400 |
| gwascentral | rs6782400 |
| openSNP | rs6782400 |
| 23andMe | rs6782400 |
| SNPshot | rs6782400 |
| SNPdbe | rs6782400 |
| MSV3d | rs6782400 |
| GWAS Ctlg | rs6782400 |
| GMAF | 0.3811 |
| Max Magnitude | 0 |
| ? | (A;A) (A;C) (C;C) | 28 |
|---|---|---|
|
| ||
[PMID 18451257] rs8178085 and rs12334811 with approaching dose-dependent effect on lung cancer predisposition, subjects carrying two to four risk genotypes were associated with a 43% decreased lung cancer risk compared with subjects carrying zero to one risk genotypes (adjusted odds ratio, 0.53; 95% confidence interval, 0.35-0.80).
Moreover, the decreased risk associated with the combined genotypes of rs8178085 and rs12334811 was slightly more pronounced in nonsmokers and in carriers with ataxia-telangiectasia mutated rs228591 variant allele or ataxia-telangiectasia and Rad3-related rs6782400 wild-type homozygous genotype.
