rs6835457
From SNPedia
| Orientation | plus |
| Stabilized | plus |
| Make rs6835457(A;A) |
| Make rs6835457(A;G) |
| Make rs6835457(G;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 4 |
| Position | 122589971 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs6835457 |
| dbSNP (classic) | rs6835457 |
| ClinGen | rs6835457 |
| ebi | rs6835457 |
| HLI | rs6835457 |
| Exac | rs6835457 |
| Gnomad | rs6835457 |
| Varsome | rs6835457 |
| LitVar | rs6835457 |
| Map | rs6835457 |
| PheGenI | rs6835457 |
| Biobank | rs6835457 |
| 1000 genomes | rs6835457 |
| hgdp | rs6835457 |
| ensembl | rs6835457 |
| geneview | rs6835457 |
| scholar | rs6835457 |
| rs6835457 | |
| pharmgkb | rs6835457 |
| gwascentral | rs6835457 |
| openSNP | rs6835457 |
| 23andMe | rs6835457 |
| SNPshot | rs6835457 |
| SNPdbe | rs6835457 |
| MSV3d | rs6835457 |
| GWAS Ctlg | rs6835457 |
| GMAF | 0.3719 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs6835457 is a SNP in the 3'-UTR flanking region of the IL21 gene.
A study including both European (4,248 patients) and African-Americans (1,569 patients) with lupus focusing on the IL2/IL21 gene region on chromosome 4q27 concluded that 2 tightly linked SNPs were associated with increased risk for the disease, rs907715 and rs6835457, with odds ratios of 1.16 (CI: 1.1-1.22, p=2x10e-8) and 1.11 (CI:1.05-1.17, p=9x10e-5), respectively.[PMID 21425124
]
[PMID 23172754] Implication of IL-2/IL-21 region in systemic sclerosis genetic susceptibility
