rs688034
From SNPedia
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | normal |
| (C;T) | 1.1 | 1.1x risk higher risk for coronary artery disease |
| (T;T) | 2 | 1.6x risk |
| Reference | GRCh38 38.1/141 |
| Chromosome | 22 |
| Position | 26293669 |
| Gene | SEZ6L |
| is a | snp |
| is | mentioned by |
| dbSNP | rs688034 |
| dbSNP (classic) | rs688034 |
| ClinGen | rs688034 |
| ebi | rs688034 |
| HLI | rs688034 |
| Exac | rs688034 |
| Gnomad | rs688034 |
| Varsome | rs688034 |
| LitVar | rs688034 |
| Map | rs688034 |
| PheGenI | rs688034 |
| Biobank | rs688034 |
| 1000 genomes | rs688034 |
| hgdp | rs688034 |
| ensembl | rs688034 |
| geneview | rs688034 |
| scholar | rs688034 |
| rs688034 | |
| pharmgkb | rs688034 |
| gwascentral | rs688034 |
| openSNP | rs688034 |
| 23andMe | rs688034 |
| SNPshot | rs688034 |
| SNPdbe | rs688034 |
| MSV3d | rs688034 |
| GWAS Ctlg | rs688034 |
| GMAF | 0.1602 |
| Max Magnitude | 2 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
rs688034 has been reported in a large study to be associated with heart disease, in particular, coronary artery disease.
The risk allele (oriented to the dbSNP entry) is (T); the odds ratio associated with heterozygotes is 1.11 (CI 0.98-1.25), and for homozygotes, 1.62 (CI 1.34-1.95). [PMID 17554300
]
| GWAS | |
|---|---|
| SNP | rs688034 |
| PubMedID | [PMID 17554300]
|
| Condition | Coronary disease |
| Gene | NR |
| Risk Allele | T |
| pValue | 4.00E-006 |
| OR | 1.11 |
| 95% CI | 0.99-1.25 |
[PMID 19956433] Genetics of coronary artery disease: focus on genome-wide association studies.
[PMID 20017983] Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring Cohort.
