rs6908425
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 2 | 1.95x increased risk of developing Crohn's disease |
| (C;T) | 1.5 | 1.63x increased risk of developing Crohn's disease |
| (T;T) | 1 | Normal risk of developing Crohn's disease |
| Reference | GRCh38 38.1/141 |
| Chromosome | 6 |
| Position | 20728500 |
| Gene | CDKAL1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs6908425 |
| dbSNP (classic) | rs6908425 |
| ClinGen | rs6908425 |
| ebi | rs6908425 |
| HLI | rs6908425 |
| Exac | rs6908425 |
| Gnomad | rs6908425 |
| Varsome | rs6908425 |
| LitVar | rs6908425 |
| Map | rs6908425 |
| PheGenI | rs6908425 |
| Biobank | rs6908425 |
| 1000 genomes | rs6908425 |
| hgdp | rs6908425 |
| ensembl | rs6908425 |
| geneview | rs6908425 |
| scholar | rs6908425 |
| rs6908425 | |
| pharmgkb | rs6908425 |
| gwascentral | rs6908425 |
| openSNP | rs6908425 |
| 23andMe | rs6908425 |
| SNPshot | rs6908425 |
| SNPdbe | rs6908425 |
| MSV3d | rs6908425 |
| GWAS Ctlg | rs6908425 |
| GMAF | 0.2172 |
| Max Magnitude | 2 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
rs6908425 has been reported in a large study to be associated with Crohn's disease.
The risk allele (oriented to the dbSNP entry) is (C); the odds ratio associated with heterozygotes is 1.63 (CI 1.38-2.25), and for homozygotes, 1.95 (CI 1.43-2.67). [PMID 17554300
]
[PMID 18923449] Further genetic evidence for three psoriasis-risk genes: ADAM33, CDKAL1, and PTPN22
| GWAS snp | |
|---|---|
| PMID | [PMID 18587394]
|
| Trait | Crohn's disease |
| Title | Genome-wide assocation defines more than 30 distinct susceptibility loci for Crohn's disease |
| Risk Allele | C |
| P-val | 8.9999999999999999E-10 |
| Odds Ratio | 1.21 [NR] |
[PMID 19587699] Differential contribution of CDKAL1 variants to psoriasis, Crohn's disease and type II diabetes
[PMID 19068216] Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.
[PMID 19422935] Genetic risk profiling and prediction of disease course in Crohn's disease patients.
[PMID 19474294] Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.
[PMID 19638187] Genetic susceptibility to psoriasis: an emerging picture.
[PMID 19915572] Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.
[PMID 20518082] Role of genetics in prediction of disease course and response to therapy.
[PMID 21304977] An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.
| GWAS snp | |
|---|---|
| PMID | [PMID 21102463]
|
| Trait | Crohn's disease |
| Title | Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. |
| Risk Allele | C |
| P-val | 1E-8 |
| Odds Ratio | 1.17 [1.11-1.23] |
[PMID 26563541] CDKAL1 gene variants affect the anti-TNF response among Psoriasis patients
