rs6922269

plus

Geno	Mag	Summary
(A;A)	2	1.6x risk of coronary artery disease
(A;G)		1.2x risk of coronary artery disease
(G;G)	0	normal

Reference

GRCh38 38.1/141

Chromosome

6

Position

150931849

Gene

MTHFD1L

is a	snp
is	mentioned by
dbSNP	rs6922269
dbSNP (classic)	rs6922269
ClinGen	rs6922269
ebi	rs6922269
HLI	rs6922269
Exac	rs6922269
Gnomad	rs6922269
Varsome	rs6922269
LitVar	rs6922269
Map	rs6922269
PheGenI	rs6922269
Biobank	rs6922269
1000 genomes	rs6922269
hgdp	rs6922269
ensembl	rs6922269
geneview	rs6922269
scholar	rs6922269
google	rs6922269
pharmgkb	rs6922269
gwascentral	rs6922269
openSNP	rs6922269
23andMe	rs6922269
SNPshot	rs6922269
SNPdbe	rs6922269
MSV3d	rs6922269
GWAS Ctlg	rs6922269

GMAF

0.2906

Max Magnitude

2

?

(A;A) (A;G) (G;G)

28

rs6922269 has been reported in a large study to be associated with heart disease, in particular, coronary artery disease.

The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with heterozygotes is 1.17 (CI 1.04-1.32), and for homozygotes, 1.65 (CI 1.32-2.06). [PMID 17554300 ]

GWAS
SNP	rs6922269
PubMedID	[PMID 17634449 ]
Condition	Coronary disease
Gene	MTHFD1L
Risk Allele	A
pValue	3.00E-008
OR	1.23
95% CI	1.15-1.33

[PMID 19164808 ] Large scale association analysis of novel genetic loci for coronary artery disease

[PMID 18675980 ] Novel genetic variants linked to coronary artery disease by genome-wide association are not associated with carotid artery intima-media thickness or intermediate risk phenotypes

[PMID 19373437] Association of three polymorphisms selected from a genome-wide association study with coronary heart disease in the Tunisian population

[PMID 21463265 ] Association of SNP rs17465637 on Chromosome 1q41 and rs599839 on 1p13.3 with Myocardial Infarction in an American Caucasian Population

[PMID 22216278 ] Large Scale Association Analysis Identifies Three Susceptibility Loci for Coronary Artery Disease

[PMID 18780302 ] Association studies of 22 candidate SNPs with late-onset Alzheimer's disease.

[PMID 18852197 ] Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.

[PMID 18979498 ] The impact of newly identified loci on coronary heart disease, stroke and total mortality in the MORGAM prospective cohorts.

[PMID 19135198] Evaluation of the association of genetic variants on the chromosomal loci 9p21.3, 6q25.1, and 2q36.3 with angiographically characterized coronary artery disease.

[PMID 19198609 ] Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.

[PMID 19336475 ] Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.

[PMID 19750184 ] Genome-wide association studies for atherosclerotic vascular disease and its risk factors.

[PMID 19956433 ] Genetics of coronary artery disease: focus on genome-wide association studies.

[PMID 20017983 ] Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring Cohort.

[PMID 21804106 ] Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration.

[PMID 22042884 ] Association of genetic variants and incident coronary heart disease in multiethnic cohorts: the PAGE study.

[PMID 25809277] Rs6922269 marker at the MTHFD1L gene predict cardiovascular mortality in males after acute coronary syndrome

[PMID 32858814 ] Association of the PSRC1 rs599839 Variant with Coronary Artery Disease in a Mexican Population.

[PMID 32916786 ] Influence of SH2B3, MTHFD1L, GGCX, and ITGB3 Gene Polymorphisms on theVariability on Warfarin Dosage Requirements and Susceptibility to CVD in the Jordanian Population.