rs7089424

plus

Geno	Mag	Summary
(G;G)	2.5	moderately (~4x) increased risk for acute lymphoblastic leukemia
(G;T)	1.5	somewhat (~2x) increased risk for acute lymphoblastic leukemia
(T;T)	0	common/normal

Reference

GRCh38 38.1/142

Chromosome

10

Position

61992400

Gene

ARID5B

is a	snp
is	mentioned by
dbSNP	rs7089424
dbSNP (classic)	rs7089424
ClinGen	rs7089424
ebi	rs7089424
HLI	rs7089424
Exac	rs7089424
Gnomad	rs7089424
Varsome	rs7089424
LitVar	rs7089424
Map	rs7089424
PheGenI	rs7089424
Biobank	rs7089424
1000 genomes	rs7089424
hgdp	rs7089424
ensembl	rs7089424
geneview	rs7089424
scholar	rs7089424
google	rs7089424
pharmgkb	rs7089424
gwascentral	rs7089424
openSNP	rs7089424
23andMe	rs7089424
SNPshot	rs7089424
SNPdbe	rs7089424
MSV3d	rs7089424
GWAS Ctlg	rs7089424

GMAF

0.3287

Max Magnitude

2.5

?

(G;G) (G;T) (T;T)

28

GWAS snp
PMID	[PMID 19684604 ]
Trait	Acute lymphoblastic leukemia (childhood)
Title	Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia
Risk Allele	C
P-val	7E-19
Odds Ratio	1.65 [1.54-1.76]

OMIM	613065
Desc
Variant
Related	also

[PMID 20460642 ] Replication analysis confirms the association of ARID5B with childhood B-cell acute lymphoblastic leukemia.

[PMID 20919861] Variation at 7p12.2 and 10q21.2 influences childhood acute lymphoblastic leukemia risk in the Thai population and may contribute to racial differences in leukemia incidence.

[PMID 25124600] Associations between AT-rich Interactive Domain 5B gene Polymorphisms and Risk of Childhood Acute Lymphoblastic Leukemia: a Meta-analysis

[PMID 25761407 ] Association of genetic variation in IKZF1, ARID5B, and CEBPE and surrogates for early-life infections with the risk of acute lymphoblastic leukemia in Hispanic children

[PMID 24707947] Genetic markers in a multi-ethnic sample for childhood acute lymphoblastic leukemia risk

[PMID 26575185 ] Somatic Mutation Allelic Ratio Test Using ddPCR (SMART-ddPCR): An Accurate Method for Assessment of Preferential Allelic Imbalance in Tumor DNA