rs7142143
From SNPedia
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 2.5 | Increased odds of relapse in treated childhood ALL patients |
| (C;T) | 2 | Increased odds of relapse in treated childhood ALL patients |
| (T;T) | 0 | common/normal |
| Reference | GRCh38 38.1/141 |
| Chromosome | 14 |
| Position | 50936813 |
| Gene | PYGL |
| is a | snp |
| is | mentioned by |
| dbSNP | rs7142143 |
| dbSNP (classic) | rs7142143 |
| ClinGen | rs7142143 |
| ebi | rs7142143 |
| HLI | rs7142143 |
| Exac | rs7142143 |
| Gnomad | rs7142143 |
| Varsome | rs7142143 |
| LitVar | rs7142143 |
| Map | rs7142143 |
| PheGenI | rs7142143 |
| Biobank | rs7142143 |
| 1000 genomes | rs7142143 |
| hgdp | rs7142143 |
| ensembl | rs7142143 |
| geneview | rs7142143 |
| scholar | rs7142143 |
| rs7142143 | |
| pharmgkb | rs7142143 |
| gwascentral | rs7142143 |
| openSNP | rs7142143 |
| 23andMe | rs7142143 |
| SNPshot | rs7142143 |
| SNPdbe | rs7142143 |
| MSV3d | rs7142143 |
| GWAS Ctlg | rs7142143 |
| GMAF | 0.0225 |
| Max Magnitude | 2.5 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
[PMID 23007406
] Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia. Each rs7142143(C) allele increases odds of relapse by 3.6x (CI: 2.34-5.57, adjusted p=1.20 × 10e−5) based on a study of 2,500 childhood acute lymphoblastic leukemia patients.
| GWAS snp | |
|---|---|
| PMID | [PMID 23007406]
|
| Trait | Acute lymphoblastic leukemia (childhood) |
| Title | Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia. |
| Risk Allele | C |
| P-val | 7E-9 |
| Odds Ratio | 3.61 [2.34-5.57] |
