rs719725
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 1.46x increased risk for colorectal cancer | |
| (A;C) | 1.5x increased risk for colorectal cancer | |
| (C;C) | 0 | normal |
| Reference | GRCh37 37.1/131 |
| Chromosome | 9 |
| Position | 6365683 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs719725 |
| dbSNP (classic) | rs719725 |
| ClinGen | rs719725 |
| ebi | rs719725 |
| HLI | rs719725 |
| Exac | rs719725 |
| Gnomad | rs719725 |
| Varsome | rs719725 |
| LitVar | rs719725 |
| Map | rs719725 |
| PheGenI | rs719725 |
| Biobank | rs719725 |
| 1000 genomes | rs719725 |
| hgdp | rs719725 |
| ensembl | rs719725 |
| geneview | rs719725 |
| scholar | rs719725 |
| rs719725 | |
| pharmgkb | rs719725 |
| gwascentral | rs719725 |
| openSNP | rs719725 |
| 23andMe | rs719725 |
| SNPshot | rs719725 |
| SNPdbe | rs719725 |
| MSV3d | rs719725 |
| GWAS Ctlg | rs719725 |
| GMAF | 0.3255 |
| Max Magnitude | 0 |
| ? | (A;A) (A;C) (C;C) | 28 |
|---|---|---|
|
| ||
rs719725 is a SNP on chromosome 9p24 that has been associated with increased risk of colorectal cancer, based on a study of 1,567 sibships from the Colon Cancer Family Registry.
By genotypes, the observed risks were as follows: (A;A) versus (C;C): odds ratios, 1.46, CI: 1.06-2.02; (A;C) versus (C;C): odds ratio 1.50, CI: 1.14-1.98; p = 0.011)[PMID 18056436]
[PMID 20978172
] Characterization of 9p24 risk locus and colorectal adenoma and cancer: gene-environment interaction and meta-analysis : gave an overall meta-analysis (n=17) OR of 1.07 (95% CI 1.03-1.12, p-trend 0.001).
[PMID 21102338] Possible association between a genetic polymorphism at 8q24 and risk of upper gastrointestinal cancer
[PMID 21119214] Colorectal Cancer Susceptibility Loci in a Population-Based Study: Associations with Morphological Parameters
[PMID 21952639] NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor
[PMID 19155440] Meta association of colorectal cancer confirms risk alleles at 8q24 and 18q21.
[PMID 20648012] Association studies on 11 published colorectal cancer risk loci.
[PMID 21071539] Generalizability and epidemiologic characterization of eleven colorectal cancer GWAS hits in multiple populations.
[PMID 23359760] Single-nucleotide polymorphism associations for colorectal cancer in southern chinese population
[PMID 22848671] Association of eleven common, low-penetrance colorectal cancer susceptibility genetic variants at six risk loci with clinical outcome.
[PMID 23434150] Are the common genetic variants associated with colorectal cancer risk for DNA mismatch repair gene mutation carriers?
[PMID 27769063] Risk of eighteen genome-wide association study-identified genetic variants for colorectal cancer and colorectal adenoma in Han Chinese.
