rs721048
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 1.9 | slightly increased prostate cancer risk |
| (A;G) | None | |
| (G;G) | 0 | normal |
| Reference | GRCh38 38.1/141 |
| Chromosome | 2 |
| Position | 62904596 |
| Gene | EHBP1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs721048 |
| dbSNP (classic) | rs721048 |
| ClinGen | rs721048 |
| ebi | rs721048 |
| HLI | rs721048 |
| Exac | rs721048 |
| Gnomad | rs721048 |
| Varsome | rs721048 |
| LitVar | rs721048 |
| Map | rs721048 |
| PheGenI | rs721048 |
| Biobank | rs721048 |
| 1000 genomes | rs721048 |
| hgdp | rs721048 |
| ensembl | rs721048 |
| geneview | rs721048 |
| scholar | rs721048 |
| rs721048 | |
| pharmgkb | rs721048 |
| gwascentral | rs721048 |
| openSNP | rs721048 |
| 23andMe | rs721048 |
| SNPshot | rs721048 |
| SNPdbe | rs721048 |
| MSV3d | rs721048 |
| GWAS Ctlg | rs721048 |
| GMAF | 0.1088 |
| Max Magnitude | 1.9 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
[PMID 18264098
] shows a significantly stronger association with more aggressive forms of prostate cancer (odds ratios (OR) = 1.15; P = 7.7 x 10(-9)).
| GWAS | |
|---|---|
| SNP | rs721048 |
| PubMedID | [PMID 18264098]
|
| Condition | Prostate cancer |
| Gene | EHBP1 |
| Risk Allele | A |
| pValue | 8.00E-009 |
| OR | 1.15 |
| 95% CI | 1.10-1.21 |
[PMID 19104501] Prostate cancer genomics: towards a new understanding.
[PMID 19318432] Generalizability of associations from prostate cancer genome-wide association studies in multiple populations.
[PMID 19434657] Individual and cumulative effect of prostate cancer risk-associated variants on clinicopathologic variables in 5,895 prostate cancer patients.
[PMID 19549807] Prostate cancer risk associated loci in African Americans.
[PMID 19567509] Genetic variants and prostate cancer risk: candidate replication and exploration of viral restriction genes.
[PMID 20039378] Estimation of genotype relative risks from pedigree data by retrospective likelihoods.
[PMID 21390317] Characterizing associations and SNP-environment interactions for GWAS-identified prostate cancer risk markers--results from BPC3.
[PMID 23405784] [Susceptibility to prostate cancer in Han Chinese: single nucleotide polymorphism analysis of 1 667 cases]
| ClinVar | |
|---|---|
| Risk | Rs721048(A;A) |
| Alt | Rs721048(A;A) |
| Reference | Rs721048(G;G) |
| Significance | Pathogenic |
| Disease | Prostate cancer |
| Variation | info |
| Gene | EHBP1 |
| CLNDBN | Prostate cancer, hereditary, 12 |
| Reversed | 0 |
| HGVS | NC_000002.11:g.63131731G>A |
| CLNSRC | OMIM Allelic Variant |
| CLNACC | RCV000001429.2, |
[PMID 26185455] Association between EHBP1 rs721048(A>G) polymorphism and prostate cancer susceptibility: a meta-analysis of 17 studies involving 150,678 subjects
[PMID 32295536] Association study between common variations in some candidate genes and prostate adenocarcinoma predisposition through multi-stage approach in Iranian population.
