rs727153
From SNPedia
| Orientation | minus |
| Stabilized | minus |
| Make rs727153(A;A) |
| Make rs727153(A;G) |
| Make rs727153(G;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 4 |
| Position | 154733269 |
| Gene | LRAT |
| is a | snp |
| is | mentioned by |
| dbSNP | rs727153 |
| dbSNP (classic) | rs727153 |
| ClinGen | rs727153 |
| ebi | rs727153 |
| HLI | rs727153 |
| Exac | rs727153 |
| Gnomad | rs727153 |
| Varsome | rs727153 |
| LitVar | rs727153 |
| Map | rs727153 |
| PheGenI | rs727153 |
| Biobank | rs727153 |
| 1000 genomes | rs727153 |
| hgdp | rs727153 |
| ensembl | rs727153 |
| geneview | rs727153 |
| scholar | rs727153 |
| rs727153 | |
| pharmgkb | rs727153 |
| gwascentral | rs727153 |
| openSNP | rs727153 |
| 23andMe | rs727153 |
| SNPshot | rs727153 |
| SNPdbe | rs727153 |
| MSV3d | rs727153 |
| GWAS Ctlg | rs727153 |
| GMAF | 0.326 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
| GWAS snp | |
|---|---|
| PMID | [PMID 18823527 ]
|
| Trait | Alzheimer's disease |
| Title | A genome-wide association study for late-onset Alzheimer's disease using DNA pooling |
| Risk Allele | C |
| P-val | 0.0000030000000000000001 |
| Odds Ratio | 1.63 [1.37-1.95] |
This SNP is near the gene for lecithin retinol acyltransferase (phosphatidylcholine-retinol O-acetyltransferase) or LRAT, which is involved in Vitamin A metabolism; the risk allele is reportedly G (in dbSNP orientation). [PMID 18823527]
[PMID 20574532] Intermediate phenotypes identify divergent pathways to Alzheimer's disease.
