| Geno
|
Mag
|
Summary
|
| (C;G)
|
3
|
Moderate decrease (~0.6x) in risk for Alzheimer's disease as well as FTD and DLB
|
| (G;G)
|
3
|
Moderate decrease (~0.6x) in risk for Alzheimer's disease as well as FTD and DLB
|
The minor allele of this variant, rs72824905 (p.Pro522Arg), found in the PLCG2 gene, is reported to somewhat reduce risk for Alzheimer's disease (OR 0.68, p = 5.38 × 10e-10). This protein is highly expressed in microglia and demonstrates immune interactions associated with AD.[PMID 28714976
]
In a 2019 study including 4,985 patients with Alzheimer's (AD), 2,437 with frontotemporal demential (FTD), and 1,446 with dementia with Lewy bodies (DLB), the rs72824905-G allele was also found to reduce risk (by about half) not only for AD but also for FTD and DLB. Perhaps for this reason (or some related reason?) rs72824905-G carriers were also more likely to live to age 90, and there was even greater prevalence of the allele among centenarians. An AlzForum post about this finding is here.[PMID 31131421]
]
