rs7301328
| Orientation | plus |
| Stabilized | plus |
| Make rs7301328(C;C) |
| Make rs7301328(C;G) |
| Make rs7301328(G;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 12 |
| Position | 13865843 |
| Gene | GRIN2B |
| is a | snp |
| is | mentioned by |
| dbSNP | rs7301328 |
| dbSNP (classic) | rs7301328 |
| ClinGen | rs7301328 |
| ebi | rs7301328 |
| HLI | rs7301328 |
| Exac | rs7301328 |
| Gnomad | rs7301328 |
| Varsome | rs7301328 |
| LitVar | rs7301328 |
| Map | rs7301328 |
| PheGenI | rs7301328 |
| Biobank | rs7301328 |
| 1000 genomes | rs7301328 |
| hgdp | rs7301328 |
| ensembl | rs7301328 |
| geneview | rs7301328 |
| scholar | rs7301328 |
| rs7301328 | |
| pharmgkb | rs7301328 |
| gwascentral | rs7301328 |
| openSNP | rs7301328 |
| 23andMe | rs7301328 |
| SNPshot | rs7301328 |
| SNPdbe | rs7301328 |
| MSV3d | rs7301328 |
| GWAS Ctlg | rs7301328 |
| GMAF | 0.4036 |
| Max Magnitude | 0 |
| ? | (C;C) (C;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs7301328 ( 366C/G / Pro122Pro ) is a SNP within GRIN2B (Glutamate [NMDA] receptor subunit epsilon-2).
[PMID 19562769] small study (consisting of 404 Parkinson's patients) found association of the CC genotype with increased incidence of impulsive control and related behaviors
no assoc. noted with
[PMID 19605943] lithium response and [PMID 19005876] bipolar disorder with any GRIN2B SNPs tested (366G/C, -200G/T and rs890)
[PMID 15542698] alcoholism
[PMID 12824739] treatment-refractory schizophrenia - 'not a major risk factor', higher mean clozapine dosage noted with the rs1806201(C;C) genotype
[PMID 19911060
] Persistence criteria for susceptibility genes for schizophrenia: a discussion from an evolutionary viewpoint.
[PMID 20537720] Positive association between GRIN2B gene and bipolar disorder in the Chinese Han Population.
[PMID 24114429] A study of N-methyl-D-aspartate receptor gene (GRIN2B) variants as predictors of treatment-resistant major depression
[PMID 23408766] Assessment of NMDA receptor genes (GRIN2A, GRIN2B and GRIN2C) as candidate genes in the development of degenerative lumbar scoliosis.
| ClinVar | |
|---|---|
| Risk | rs7301328(C;C) rs7301328(T;T) |
| Alt | rs7301328(C;C) rs7301328(T;T) |
| Reference | rs7301328(G;G) |
| Significance | Other |
| Disease | not specified Intellectual Disability |
| Variation | info |
| Gene | GRIN2B |
| CLNDBN | not specified Intellectual Disability, Dominant |
| Reversed | 0 |
| HGVS | NC_000012.11:g.14018777G>C |
| CLNSRC | ClinVar GeneDx University of Chicago |
| CLNACC | RCV000117198.3, RCV000259325.1, |
[PMID 32037472] The association between eating behavior and polymorphisms in GRIN2B, GRIK3, GRIA1 and GRIN1 genes in people with type 2 diabetes mellitus.
