rs744166
| Orientation | minus |
| Stabilized | minus |
| Make rs744166(C;C) |
| Make rs744166(C;T) |
| Make rs744166(T;T) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 17 |
| Position | 42362183 |
| Gene | STAT3 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs744166 |
| dbSNP (classic) | rs744166 |
| ClinGen | rs744166 |
| ebi | rs744166 |
| HLI | rs744166 |
| Exac | rs744166 |
| Gnomad | rs744166 |
| Varsome | rs744166 |
| LitVar | rs744166 |
| Map | rs744166 |
| PheGenI | rs744166 |
| Biobank | rs744166 |
| 1000 genomes | rs744166 |
| hgdp | rs744166 |
| ensembl | rs744166 |
| geneview | rs744166 |
| scholar | rs744166 |
| rs744166 | |
| pharmgkb | rs744166 |
| gwascentral | rs744166 |
| openSNP | rs744166 |
| 23andMe | rs744166 |
| SNPshot | rs744166 |
| SNPdbe | rs744166 |
| MSV3d | rs744166 |
| GWAS Ctlg | rs744166 |
| GMAF | 0.4541 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
| GWAS | |
|---|---|
| SNP | rs744166 |
| PubMedID | [PMID 18587394 ]
|
| Condition | Crohn's disease |
| Gene | STAT3 |
| Risk Allele | A |
| pValue | 7.00E-012 |
| OR | 1.18 |
| 95% CI | |
[PMID 19776189] Dietary saturated fat modulates the association between STAT3 polymorphisms and abdominal obesity in adults
[PMID 20109474] Genetic factors in chronic inflammation: single nucleotide polymorphisms in the STAT-JAK pathway, susceptibility to DNA damage and Crohn's disease in a New Zealand population
[PMID 20159113] Genome-wide Association Study in a High-Risk Isolate for Multiple Sclerosis Reveals Associated Variants in STAT3 Gene
[PMID 20222910] Susceptibility loci reported in genome-wide association studies are associated with Crohn's disease in Canadian children
[PMID 22205606] JAK2 and STAT3 polymorphisms in a Han Chinese Population with Behcet's disease
[PMID 22269120] Investigation of JAK2, STAT3 and CCR6 polymorphisms and their gene-gene interactions in inflammatory bowel disease
[PMID 15657875] Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus.
[PMID 18978678] Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts.
[PMID 19068216] Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.
[PMID 19557189] Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.
[PMID 19653082] Strong evidence of a combination polymorphism of the tyrosine kinase 2 gene and the signal transducer and activator of transcription 3 gene as a DNA-based biomarker for susceptibility to Crohn's disease in the Japanese population.
[PMID 19915572] Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.
[PMID 20179083] No association between myeloproliferative neoplasms and the Crohn's disease-associated STAT3 predisposition SNP rs744166.
[PMID 20200543] STAT3 locus in inflammatory bowel disease and multiple sclerosis susceptibility.
[PMID 20405052] The effect of single nucleotide polymorphisms from genome wide association studies in multiple sclerosis on gene expression.
[PMID 20454450] Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset.
[PMID 21304977] An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.
[PMID 22065112] The JAK2 variant rs10758669 in Crohn's disease: altering the intestinal barrier as one mechanism of action.
[PMID 22095036] Independent replication of STAT3 association with multiple sclerosis risk in a large German case-control sample.
[PMID 23127549] Influence of the STAT3 genetic variants in the susceptibility to psoriatic arthritis and Behcet's disease
[PMID 23611997] JAK1, but not JAK2 and STAT3, confers susceptibility to Vogt-Koyanagi-Harada (VKH) syndrome in a Han Chinese population
[PMID 24081513] Association of single-nucleotide polymorphisms in the STAT3 gene with autoimmune thyroid disease in Chinese individuals
[PMID 24864251] rs744166 Polymorphism of the STAT3 Gene Is Associated with Risk of Gastric Cancer in a Chinese Population
[PMID 25132422] An analysis of genetic factors related to risk of inflammatory bowel disease and colon cancer
[PMID 26186918] STAT3 polymorphism and Helicobacter pylori CagA strains with higher number of EPIYA-C segments independently increase the risk of gastric cancer
[PMID 26204395] Single nucleotide polymorphisms in the STAT3 gene influence AITD susceptibility, thyroid autoantibody levels, and IL6 and IL17 secretion
[PMID 29228965] Genetic polymorphism in ATG16L1 gene is associated with adalimumab use in inflammatory bowel disease.
