rs746071566
From SNPedia
| Orientation | plus |
| Stabilized | plus |
| Make rs746071566(-;-) |
| Make rs746071566(-;GGAGTC) |
| Make rs746071566(GGAGTC;GGAGTC) |
| is a | snp |
| is | mentioned by |
| dbSNP | rs746071566 |
| dbSNP (classic) | rs746071566 |
| ClinGen | rs746071566 |
| ebi | rs746071566 |
| HLI | rs746071566 |
| Exac | rs746071566 |
| Gnomad | rs746071566 |
| Varsome | rs746071566 |
| LitVar | rs746071566 |
| Map | rs746071566 |
| PheGenI | rs746071566 |
| Biobank | rs746071566 |
| 1000 genomes | rs746071566 |
| hgdp | rs746071566 |
| ensembl | rs746071566 |
| geneview | rs746071566 |
| scholar | rs746071566 |
| rs746071566 | |
| pharmgkb | rs746071566 |
| gwascentral | rs746071566 |
| openSNP | rs746071566 |
| 23andMe | rs746071566 |
| SNPshot | rs746071566 |
| SNPdbe | rs746071566 |
| MSV3d | rs746071566 |
| GWAS Ctlg | rs746071566 |
| Max Magnitude | 0 |
aka c.50_55dup and c.36_37insGGAGTC (p.Val18_Val19insGlyVal)
According to OMIM, this 6-bp insertion variant is often in high linkage disequilibrium with the R139C allele (rs116855232) and the presence of both variants defined the common NUDT15 haplotype *2, which has severely decreased enzyme activity and is therefore associated with thiopurine intolerance.
