Have questions? Visit https://www.reddit.com/r/SNPedia

rs7498665

From SNPedia

Orientationplus
Stabilizedplus
Make rs7498665(A;A)
Make rs7498665(A;G)
Make rs7498665(G;G)
ReferenceGRCh38 38.1/141
Chromosome16
Position28871920
GeneSH2B1
is asnp
is mentioned by
dbSNPrs7498665
dbSNP (classic)rs7498665
ClinGenrs7498665
ebirs7498665
HLIrs7498665
Exacrs7498665
Gnomadrs7498665
Varsomers7498665
LitVarrs7498665
Maprs7498665
PheGenIrs7498665
Biobankrs7498665
1000 genomesrs7498665
hgdprs7498665
ensemblrs7498665
geneviewrs7498665
scholarrs7498665
googlers7498665
pharmgkbrs7498665
gwascentralrs7498665
openSNPrs7498665
23andMers7498665
SNPshotrs7498665
SNPdbers7498665
MSV3drs7498665
GWAS Ctlgrs7498665
GMAF0.2654
Max Magnitude0
? (A;A) (A;G) (G;G) 28


[PMID 19164386OA-icon.png] obesity and type-2 diabetes

GWAS snp
PMID [PMID 19079260]
Trait Body mass index
Title Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
Risk Allele G
P-val 3E-10
Odds Ratio 3.63 [2.49-4.77] % SD
GWAS snp
PMID [PMID 19079261OA-icon.png]
Trait Body mass index
Title Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
Risk Allele G
P-val 5E-11
Odds Ratio 0.15 [0.08-0.21] kg/m2 increase


[PMID 20386550OA-icon.png] Genes and lifestyle factors in obesity: results from 12 462 subjects from MONICA/KORA

OMIM601665
Desc
Variant
Relatedalso
OMIM613444
Desc
Variant
Relatedalso


[PMID 21796141] Computed tomography analysis of the association between the SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area


[PMID 21912638OA-icon.png] Studies of metabolic phenotypic correlates of 15 obesity associated gene variants


[PMID 21907990OA-icon.png] The SH2B1 obesity locus is associated with myocardial infarction in diabetic patients and with NO synthase activity in endothelial cells


[PMID 22248999OA-icon.png] Replication of the SH2B1 rs7498665 association with obesity in a Belgian study population


[PMID 22083549] Study of eight GWAS-identified common variants for association with obesity-related indices in Chinese children at puberty


[PMID 17228025OA-icon.png] The SH2B gene is associated with serum leptin and body fat in normal female twins.


[PMID 19478790OA-icon.png] The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI.


[PMID 19526209OA-icon.png] Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?


[PMID 19553259OA-icon.png] Common body mass index-associated variants confer risk of extreme obesity.


[PMID 19910938] Novel obesity risk loci do not determine distribution of body fat depots: a whole-body MRI/MRS study.


[PMID 20127379OA-icon.png] From monogenic to polygenic obesity: recent advances.


[PMID 20369022OA-icon.png] Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations.


[PMID 20712903OA-icon.png] Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.


[PMID 20725061OA-icon.png] MC4R variant is associated with BMI but not response to resistance training in young females.


[PMID 20824172OA-icon.png] Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study.


[PMID 21283731OA-icon.png] FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome.


[PMID 23270367OA-icon.png] Mutation screen in the GWAS derived obesity gene SH2B1 including functional analyses of detected variants


[PMID 23519644] Analyses of Non-Synonymous Obesity Risk Alleles in SH2B1 (rs7498665) and APOB48R (rs180743) in Obese Children and Adolescents Undergoing a 1-year Lifestyle Intervention

GWAS snp
PMID [PMID 23563607OA-icon.png]
Trait Obesity
Title Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
Risk Allele G
P-val 3E-13
Odds Ratio 1.07 [NR]


[PMID 24621099OA-icon.png] Meta-analyses between 18 candidate genetic markers and overweight/obesity


[PMID 23640704] Common variants near BDNF and SH2B1 show nominal evidence of association with snacking behavior in European populations


[PMID 32228543OA-icon.png] Obesity-related loci in TMEM18, CDKAL1 and FAIM2 are associated with obesity and type 2 diabetes in Chinese Han patients.