rs7524102

plus

Geno	Mag	Summary
(A;A)	0	common in complete genomics

Make rs7524102(A;G)

Make rs7524102(G;G)

Reference

GRCh38 38.1/141

Chromosome

1

Position

22371954

Gene

ZBTB40

is a	snp
is	mentioned by
dbSNP	rs7524102
dbSNP (classic)	rs7524102
ClinGen	rs7524102
ebi	rs7524102
HLI	rs7524102
Exac	rs7524102
Gnomad	rs7524102
Varsome	rs7524102
LitVar	rs7524102
Map	rs7524102
PheGenI	rs7524102
Biobank	rs7524102
1000 genomes	rs7524102
hgdp	rs7524102
ensembl	rs7524102
geneview	rs7524102
scholar	rs7524102
google	rs7524102
pharmgkb	rs7524102
gwascentral	rs7524102
openSNP	rs7524102
23andMe	rs7524102
SNPshot	rs7524102
SNPdbe	rs7524102
MSV3d	rs7524102
GWAS Ctlg	rs7524102

GMAF

0.2259

Max Magnitude

0

?

(A;A) (A;G) (G;G)

28

Rs7524102
PubMed	[PMID 18445777]
Affy Probeset	SNP_A-2092875
Affy Orientation	same
On GW 5.0
Alleles A/B	/
Ancestral	G
Population	Caucasian
Allele	A
Case Freq.
Control Freq.
Odds Ratio Het
Odds Ratio Hom
Odds Ratio All	-
Disease	Bone mineral density, lower (BMD-L)

rs7524102 increases susceptibility to Bone mineral density variations, lower for carriers of the A allele [PMID 18445777]

rs7524102 increases susceptibility to Osteoporotic fractures 1.12 times for carriers of the A allele [PMID 18445777]

GWAS
SNP	rs7524102
PubMedID	[PMID 18445777]
Condition	Bone mineral density (spine)
Gene	ZBTB40
Risk Allele	A
pValue	9.00E-009
OR	0.11
95% CI	0.07-0.15) SD decreas

GWAS snp
PMID	[PMID 19079262]
Trait	Bone mineral density (hip)
Title	New sequence variants associated with bone mineral density
Risk Allele	A
P-val	1E-16
Odds Ratio	0.15 [0.11-0.18] SD decrease

OMIM	606928
Desc	BONE MINERAL DENSITY QUANTITATIVE TRAIT LOCUS 3; BMND3
Variant
Related	also

OMIM	612106
Desc	ZINC FINGER- AND BTB DOMAIN-CONTAINING PROTEIN 40; ZBTB40
Variant
Related	also

GWAS snp
PMID	[PMID 19801982 ]
Trait	Bone mineral density (spine)
Title	Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies
Risk Allele	G
P-val	3E-10
Odds Ratio	0.09 [0.06-0.12] sd increase

GWAS snp
PMID	[PMID 19915572 ]
Trait	Ulcerative colitis
Title	Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region
Risk Allele	A
P-val	3E-7
Odds Ratio	1.10 [1.00-1.21]

GWAS snp
PMID	[PMID 21297633 ]
Trait
Title	Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
Risk Allele	A
P-val	2E-13
Odds Ratio	1.1000 [1.05-1.16]

GWAS snp
PMID	[PMID 21533022 ]
Trait
Title	Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk.
Risk Allele	G
P-val	9E-7
Odds Ratio	0.4400 [NR] unit decrease

GWAS snp
PMID	[PMID 21732829]
Trait
Title	Wnt signaling and Dupuytren's disease.
Risk Allele	G
P-val	3E-9
Odds Ratio	1.2800 None

[PMID 22824048] Opposite associations of osteoprotegerin and ZBTB40 polymorphisms with bone mineral density of the hip in postmenopausal Taiwanese women

[PMID 19181680 ] Common variants in the region around Osterix are associated with bone mineral density and growth in childhood.

[PMID 19629617 ] Replication study of candidate genes/loci associated with osteoporosis based on genome-wide screening.

[PMID 20534768 ] OPG and RANK polymorphisms are both associated with cortical bone mineral density: findings from a metaanalysis of the Avon longitudinal study of parents and children and gothenburg osteoporosis and obesity determinants cohorts.

[PMID 20554715] Analysis of recently identified osteoporosis susceptibility genes in Han Chinese women.